Plasma Membrane‐Derived Biomimetic Apoptotic Nanovesicles Targeting Inflammation and Cartilage Degeneration for Osteoarthritis

Author:

Li Zongyi123,Cheng Quhan4,Lin Luoyao123,Fu Xiaoling235ORCID,Wang Yingjun123

Affiliation:

1. School of Materials Science and Engineering South China University of Technology Guangzhou 510641 China

2. National Engineering Research Center for Tissue Restoration and Reconstruction and Innovation Center for Tissue Restoration and Reconstruction Guangzhou 510006 China

3. Laboratory of Biomedical Engineering of Guangdong Province South China University of Technology Guangzhou 510006 China

4. Key Laboratory of Bioactive Materials Ministry of Education College of Life Sciences Nankai University Tianjin 300071 China

5. School of Biomedical Sciences and Engineering South China University of Technology Guangzhou International Campus Guangzhou 511442 China

Abstract

AbstractOsteoarthritis (OA) is a degenerative whole‐joint disease in which the synovium and joint cartilage become inflamed and damaged. The essential role of inflammation in the development of OA has been recognized recently. Accordingly, simultaneous regulation of local inflammation and tissue degeneration is proposed as a promising therapeutic strategy. Herein, multifunctional biomimetic apoptotic nanovesicles (Apo‐NVs) are constructed with plasma membrane derived from apoptotic T cells. The anti‐inflammatory microRNA‐124 is further encapsulated into Apo‐NVs in the hope of achieving an enhanced immunomodulatory effect. It is found that apoptotic nanovesicles, including Apo‐NVs and Apo‐NVs‐miR‐124, both efficiently promote the M2 repolarization of M1 macrophages and inhibit the degenerative phenotype of chondrocytes. Further in vivo studies show that Apo‐NVs and Apo‐NVs‐miR‐124 alleviate synovial inflammation and protect cartilage tissue from degeneration in OA mice. The study highlights the potential of Apo‐NVs in treating OA and other inflammation‐related diseases.

Funder

National Natural Science Foundation of China

National Key Research and Development Program of China

Basic and Applied Basic Research Foundation of Guangdong Province

Key Technologies Research and Development Program of Guangzhou Municipality

Publisher

Wiley

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