Breaking down barriers: The potential of smarter CAR‐engineered NK cells against solid tumors

Author:

Khawar Muhammad B.123ORCID,Gao Guangzhong4,Rafiq Mussarat5,Shehzadi Anila6,Afzal Ali6ORCID,Abbasi Muddasir H.7,Sheikh Nadeem5,Afzal Nimra6,Ashraf Muhammad A.8,Hamid Syeda E.6,Shahzaman Sara6,Kawish Naseer5,Sun Haibo12

Affiliation:

1. Institute of Translational Medicine, Medical College Yangzhou University Yangzhou China

2. Jiangsu Key Laboratory of Experimental and, Translational Noncoding RNA Research Yangzhou China

3. Department of Zoology, Applied Molecular Biology and Biomedicine Lab University of Narowal Narowal Pakistan

4. Department of Physiatry Haian Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Chinese Medicine Nantong Jiangsu China

5. Cell & Molecular Biology Lab, Institute of Zoology University of the Punjab Lahore Pakistan

6. Department of Zoology, Molecular Medicine and Cancer Therapeutics Lab University of Central Punjab Lahore Pakistan

7. Department of Zoology University of Okara Punjab Pakistan

8. Department of Zoology University of Education Lahore Pakistan

Abstract

AbstractNatural killer (NK) cells are considered to be the foremost fighters of our innate immune system against foreign invaders and thus tend to promptly latch onto the virus‐infected and tumor/cancerous cells, killing them through phagocytosis. At present, the application of genetically engineered Chimeric antigen receptor (CAR) receptors ensures a guaranteed optimistic response with NK cells and would not allow the affected cells to dodge or escape unchecked. Hence the specificity and uniqueness of CAR‐NK cells over CAR‐T therapy make them a better immunotherapeutic choice to reduce the load of trafficking of numerous tumor cells near the healthy cell populations in a more intact way than offered by CAR‐T immunotherapy. Our review mainly focuses on the preclinical, clinical, and recent advances in clinical research trials and further strategies to achieve an augmented and efficient cure against solid tumors.

Publisher

Wiley

Subject

Cell Biology,Molecular Biology,Biochemistry

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