The genomics of heart failure: design and rationale of the HERMES consortium

Author:

Lumbers R. Thomas123,Shah Sonia45,Lin Honghuang67,Czuba Tomasz8,Henry Albert15,Swerdlow Daniel I.59,Mälarstig Anders1011,Andersson Charlotte712,Verweij Niek13,Holmes Michael V.141516,Ärnlöv Johan1718,Svensson Per1920,Hemingway Harry1221,Sallah Neneh1222,Almgren Peter23,Aragam Krishna G.242526,Asselin Geraldine27,Backman Joshua D.28,Biggs Mary L.2930,Bloom Heather L.31,Boersma Eric32,Brandimarto Jeffrey33,Brown Michael R.34,Brunner‐La Rocca Hans‐Peter35,Carey David J.36,Chaffin Mark D.37,Chasman Daniel I.3839,Chazara Olympe40,Chen Xing10,Chen Xu41,Chung Jonathan H.28,Chutkow William42,Cleland John G.F.4344,Cook James P.45,Denus Simon2746,Dehghan Abbas4748,Delgado Graciela E.49,Denaxas Spiros122150,Doney Alexander S.51,Dörr Marcus5253,Dudley Samuel C.54,Engström Gunnar23,Esko Tõnu2455,Fatemifar Ghazaleh12,Felix Stephan B.5253,Finan Chris5,Ford Ian43,Fougerousse Francoise56,Fouodjio René27,Ghanbari Mohsen57,Ghasemi Sahar5358,Giedraitis Vilmantas59,Giulianini Franco38,Gottdiener John S.60,Gross Stefan5253,Guðbjartsson Daníel F.6162,Gui Hongsheng63,Gutmann Rebecca64,Haggerty Christopher M.65,Harst Pim136667,Hedman Åsa K.11,Helgadottir Anna61,Hillege Hans13,Hyde Craig L.10,Jacob Jaison42,Jukema J. Wouter6869,Kamanu Frederick3770,Kardys Isabella32,Kavousi Maryam57,Khaw Kay‐Tee71,Kleber Marcus E.49,Køber Lars72,Koekemoer Andrea73,Kraus Bill74,Kuchenbaecker Karoline2275,Langenberg Claudia76,Lind Lars77,Lindgren Cecilia M.247879,London Barry80,Lotta Luca A.76,Lovering Ruth C.5,Luan Jian'an76,Magnusson Patrik41,Mahajan Anubha81,Mann Douglas82,Margulies Kenneth B.33,Marston Nicholas A.70,März Winfried498384,McMurray John J.V.85,Melander Olle86,Melloni Giorgio3770,Mordi Ify R.51,Morley Michael P.33,Morris Andrew D.87,Morris Andrew P.4579,Morrison Alanna C.34,Nagle Michael W.10,Nelson Christopher P.73,Newton‐Cheh Christopher2688,Niessner Alexander89,Niiranen Teemu9091,Nowak Christoph17,O'Donoghue Michelle L.70,Owens Anjali T.33,Palmer Colin N.A.51,Paré Guillaume92,Perola Markus93,Perreault Louis‐Philippe Lemieux27,Portilla‐Fernandez Eliana5794,Psaty Bruce M.3095,Rice Kenneth M.29,Ridker Paul M.3839,Romaine Simon P.R.73,Roselli Carolina1337,Rotter Jerome I.96,Ruff Christian T.70,Sabatine Marc S.70,Salo Perttu90,Salomaa Veikko90,Setten Jessica97,Shalaby Alaa A.98,Smelser Diane T.36,Smith Nicholas L.9599100,Stefansson Kari61101,Stender Steen102,Stott David J.103,Sveinbjörnsson Garðar61,Tammesoo Mari‐Liis55,Tardif Jean‐Claude27104,Taylor Kent D.96,Teder‐Laving Maris55,Teumer Alexander5358,Thorgeirsson Guðmundur61101,Thorsteinsdottir Unnur61101,Torp‐Pedersen Christian105106107,Trompet Stella68108,Tuckwell Danny42,Tyl Benoit56,Uitterlinden Andre G.57109,Vaura Felix90110,Veluchamy Abirami51,Visscher Peter M.4,Völker Uwe53111,Voors Adriaan A.13,Wang Xiaosong42,Wareham Nicholas J.76,Weeke Peter E.72,Weiss Raul112,White Harvey D.113,Wiggins Kerri L.114,Xing Heming42,Yang Jian4,Yang Yifan33,Yerges‐Armstrong Laura M.115,Yu Bing34,Zannad Faiez116,Zhao Faye42,Wilk Jemma B.10,Holm Hilma61,Sattar Naveed85,Lubitz Steven A.24117,Lanfear David E.63118,Shah Svati74119120,Dunn Michael E.121,Wells Quinn S.122,Asselbergs Folkert W.23597,Hingorani Aroon D.35,Dubé Marie‐Pierre27104,Samani Nilesh J.73,Lang Chim C.51,Cappola Thomas P.33,Ellinor Patrick T.37117,Vasan Ramachandran S.7123,Smith J. Gustav824124125,

Affiliation:

1. Institute of Health Informatics University College London Gower St London WC1E 7HB UK

2. Health Data Research UK London University College London London UK

3. BHF Research Accelerator University College London London UK

4. Institute for Molecular Bioscience The University of Queensland Brisbane Queensland Australia

5. Institute of Cardiovascular Science University College London London UK

6. Section of Computational Biomedicine, Department of Medicine Boston University School of Medicine Boston MA USA

7. National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study Framingham MA USA

8. Department of Cardiology, Clinical Sciences Lund University and Skåne University Hospital Lund Sweden

9. Department of Medicine Imperial College London London UK

10. Pfizer Worldwide Research & Development Cambridge MA USA

11. Cardiovascular Medicine Unit, Department of Medicine Solna Karolinska Institute Stockholm Sweden

12. Department of Cardiology Herlev Gentofte Hospital Herlev Denmark

13. Department of Cardiology University of Groningen, University Medical Center Groningen Groningen The Netherlands

14. Medical Research Council Population Health Research Unit at the University of Oxford Oxford UK

15. Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, Big Data Institute University of Oxford Oxford UK

16. National Institute for Health Research Oxford Biomedical Research Centre Oxford University Hospital Oxford UK

17. Department of Neurobiology, Care Sciences and Society/Section of Family Medicine and Primary Care Karolinska Institutet Stockholm Sweden

18. School of Health and Social Sciences Dalarna University Falun Sweden

19. Department of Clinical Science and Education Karolinska Institutet, Södersjukhuset Stockholm Sweden

20. Department of Cardiology Södersjukhuset Stockholm Sweden

21. The National Institute for Health Research University College London Hospitals Biomedical Research Centre, University College London London UK

22. UCL Genetics Institute University College London London UK

23. Department of Clinical Sciences Lund University Malmö Sweden

24. Program in Medical and Population Genetics The Broad Institute of MIT and Harvard Cambridge MA USA

25. Center for Genomic Medicine Massachusetts General Hospital Boston MA USA

26. Cardiovascular Research Center Massachusetts General Hospital Boston MA USA

27. Montreal Heart Institute Montreal Quebec Canada

28. Regeneron Genetics Center Tarrytown NY USA

29. Department of Biostatistics University of Washington Seattle WA USA

30. Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology and Health Services University of Washington Seattle WA USA

31. Division of Cardiology, Department of Medicine Emory University Medical Center Atlanta GA USA

32. Erasmus MC University Medical Center Rotterdam Rotterdam The Netherlands

33. Penn Cardiovascular Institute, Perelman School of Medicine University of Pennsylvania Philadelphia PA USA

34. Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health The University of Texas Health Science Center at Houston Houston TX USA

35. Maastricht University Medical Center Maastricht The Netherlands

36. Department of Molecular and Functional Genomics Geisinger Danville PA USA

37. Cardiovascular Disease Initiative The Broad Institute of MIT and Harvard Cambridge MA USA

38. Division of Preventive Medicine Brigham and Women's Hospital Boston MA USA

39. Harvard Medical School Boston MA USA

40. Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D AstraZeneca Cambridge UK

41. Department of Medical Epidemiology and Biostatistics Karolinska Institutet Stockholm Sweden

42. Novartis Institutes for Biomedical Research Cambridge MA USA

43. Robertson Centre for Biostatistics & Glasgow Clinical Trials Unit, Institute of Health and Wellbeing University of Glasgow, Glasgow Royal Infirmary Glasgow UK

44. National Heart and Lung Institute Imperial College London UK

45. Department of Biostatistics University of Liverpool Liverpool UK

46. Faculty of Pharmacy Université de Montréal Montreal Quebec Canada

47. Department of Epidemiology and Biostatistics Imperial College London, St Mary's Campus London UK

48. MRC‐PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics Imperial College London, St Mary's Campus London UK

49. Vth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim University of Heidelberg Heidelberg Germany

50. The Alan Turing Institute, British Library London UK

51. Division of Molecular and Clinical Medicine University of Dundee, Ninewells Hospital and Medical School Dundee UK

52. Department of Internal Medicine B University Medicine Greifswald Greifswald Germany

53. DZHK (German Center for Cardiovascular Research), partner site Greifswald Greifswald Germany

54. Cardiovascular Division, Department of Medicine University of Minnesota Minneapolis MN USA

55. Estonian Genome Center, Institute of Genomics University of Tartu Tartu Estonia

56. Translational and Clinical Research Servier Cardiovascular Center for Therapeutic Innovation Suresnes France

57. Department of Epidemiology Erasmus University Medical Center Rotterdam The Netherlands

58. Institute for Community Medicine University Medicine Greifswald Greifswald Germany

59. Department of Public Health and Caring Sciences, Geriatrics Uppsala University Uppsala Sweden

60. Department of Medicine, Division of Cardiology University of Maryland School of Medicine Baltimore MD USA

61. deCODE genetics/Amgen Inc. Reykjavik Iceland

62. School of Engineering and Natural Sciences University of Iceland Reykjavik Iceland

63. Center for Individualized and Genomic Medicine Research, Department of Internal Medicine Henry Ford Hospital Detroit MI USA

64. Division of Cardiovascular Medicine University of Iowa Carver College of Medicine Iowa City IA USA

65. Department of Translational Data Science and Informatics Geisinger Danville PA USA

66. Department of Genetics University of Groningen, University Medical Center Groningen Groningen The Netherlands

67. Durrer Center for Cardiogenetic Research ICIN‐Netherlands Heart Institute Utrecht The Netherlands

68. Department of Cardiology Leiden University Medical Center Leiden The Netherlands

69. Netherlands Heart Institute Utrecht The Netherlands

70. TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital Harvard Medical School Boston MA USA

71. Department of Public Health and Primary Care University of Cambridge Cambridge UK

72. Department of Cardiology Copenhagen University Hospital Rigshospitalet Copenhagen Denmark

73. Department of Cardiovascular Sciences University of Leicester and NIHR Leicester Biomedical Research Centre, Glenfield Hospital Leicester UK

74. Duke Molecular Physiology Institute Durham NC USA

75. Division of Psychiatry University College of London London UK

76. MRC Epidemiology Unit, Institute of Metabolic Science University of Cambridge School of Clinical Medicine Cambridge UK

77. Department of Medical Sciences Uppsala University Uppsala Sweden

78. Big Data Institute at the Li Ka Shing Centre for Health Information and Discovery University of Oxford Oxford UK

79. Wellcome Trust Centre for Human Genetics University of Oxford Oxford UK

80. Division of Cardiovascular Medicine and Abboud Cardiovascular Research Center University of Iowa Iowa City IA USA

81. Genentech Inc. San Francisco CA USA

82. Center for Cardiovascular Research, Division of Cardiology, Department of Medicine Washington University School of Medicine St. Louis MO USA

83. Synlab Academy Synlab Holding Deutschland GmbH Mannheim Germany

84. Clinical Institute of Medical and Chemical Laboratory Diagnostics Medical University of Graz Graz Austria

85. BHF Cardiovascular Research Centre University of Glasgow Glasgow UK

86. Department of Internal Medicine, Clinical Sciences Lund University and Skåne University Hospital Malmö Sweden

87. Usher Institute of Population Health Sciences and Informatics University of Edinburgh Edinburgh UK

88. Center for Human Genetic Research Massachusetts General Hospital Boston MA USA

89. Department of Internal Medicine II, Division of Cardiology Medical University of Vienna Vienna Austria

90. Finnish Institute for Health and Welfare Helsinki Finland

91. Department of Medicine Turku University Hospital and University of Turku Turku Finland

92. Department of Pathology and Molecular Medicine McMaster University Hamilton Ontario Canada

93. National Institute for Health and Welfare Helsinki Finland

94. Division of Vascular Medicine and Pharmacology, Department of Internal Medicine Erasmus University Medical Center Rotterdam The Netherlands

95. Kaiser Permanente Washington Health Research Institute Kaiser Permanente Washington Seattle WA USA

96. The Institute for Translational Genomics and Population Sciences, Department of Pediatrics The Lundquist Institute for Biomedical Innovation at Harbor‐UCLA Medical Center Torrance CA USA

97. Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht University of Utrecht Utrecht The Netherlands

98. Division of Cardiology, Department of Medicine University of Pittsburgh Medical Center and VA Pittsburgh HCS Pittsburgh PA USA

99. Department of Epidemiology University of Washington Seattle WA USA

100. Department of Veterans Affairs Office of Research and Development Seattle Epidemiologic Research and Information Center Seattle WA USA

101. Faculty of Medicine, Department of Medicine University of Iceland Reykjavik Iceland

102. Department of Clinical Biochemistry Copenhagen University Hospital Herlev and Gentofte Denmark

103. Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences University of Glasgow Glasgow UK

104. Faculty of Medicine Université de Montréal Montreal Quebec Canada

105. Department of Epidemiology and Biostatistics Aalborg University Hospital Aalborg Denmark

106. Department of Health, Science and Technology Aalborg University Hospital Aalborg Denmark

107. Department of Cardiology Aalborg University Hospital Aalborg Denmark

108. Section of Gerontology and Geriatrics, Department of Internal Medicine Leiden University Medical Center Leiden The Netherlands

109. Department of Internal Medicine, Erasmus MC University Medical Center Rotterdam Rotterdam The Netherlands

110. Department of Clinical Medicine University of Turku Turku Finland

111. Interfaculty Institute for Genetics and Functional Genomics University Medicine Greifswald Greifswald Germany

112. Division of Cardiovascular Medicine, Department of Internal Medicine The Ohio State University Medical Center Columbus OH USA

113. Green Lane Cardiovascular Service Auckland City Hospital Auckland New Zealand

114. Department of Medicine University of Washington Seattle WA USA

115. Human Genetics GlaxoSmithKline Collegeville PA USA

116. CHU de Nancy, Inserm and INI‐CRCT (F‐CRIN), Institut Lorrain du Coeur et des Vaisseaux Université de Lorraine Nancy France

117. Cardiac Arrhythmia Service and Cardiovascular Research Center Massachusetts General Hospital Boston MA USA

118. Heart and Vascular Institute Henry Ford Hospital Detroit MI USA

119. Division of Cardiology, Department of Medicine Duke University Medical Center Durham NC USA

120. Duke Clinical Research Institute Durham NC USA

121. Regeneron Pharmaceuticals Cardiovascular Research Tarrytown NY USA

122. Division of Cardiovascular Medicine and the Vanderbilt Translational and Clinical Cardiovascular Research Center Vanderbilt University Nashville TN USA

123. Sections of Cardiology, Preventive Medicine and Epidemiology, Department of Medicine Boston University Schools of Medicine and Public Health Boston MA USA

124. Wallenberg Center for Molecular Medicine and Lund University Diabetes Center Lund University Lund Sweden

125. The Wallenberg Laboratory/Department of Molecular and Clinical Medicine, Institute of Medicine, Gothenburg University and the Department of Cardiology Sahlgrenska University Hospital Gothenburg Sweden

Funder

Stiftelsen för Strategisk Forskning

Knut och Alice Wallenbergs Stiftelse

Skånes universitetssjukhus

Crafoordska Stiftelsen

European Research Council

Vetenskapsrådet

Hjärt-Lungfonden

Department of Orthopaedic Surgery, Boston University School of Medicine

Evans Medical Foundation

Framingham Heart Study

American Heart Association

National Heart, Lung, and Blood Institute

National Center for Advancing Translational Sciences

National Institutes of Health

UCLH Biomedical Research Centre

Publisher

Wiley

Subject

Cardiology and Cardiovascular Medicine

Reference30 articles.

1. Epidemiology and aetiology of heart failure

2. 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure

3. Beta‐blockers and inhibitors of the renin‐angiotensin aldosterone system for chronic heart failure with preserved ejection fraction;Martin N;Cochrane Database Syst Rev (Online),2018

4. The human subject: an integrative animal model for 21(st) century heart failure research;Chandrasekera PC;Am J Transl Res,2015

5. Genome-wide association studies of late-onset cardiovascular disease

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