Metabolism and disposition of oseltamivir (OS) in rats, determined by immunohistochemistry with monospecific antibody for OS or its active metabolite oseltamivir carboxylate (OC): A possibility of transporters dividing the drugs’ excretion into the bile and kidney
Author:
Affiliation:
1. Department of Applied Life Science Faculty of Biotechnology and Life Science Sojo University Kumamoto Japan
2. Department of Molecular Biology The Jikei University School of Medicine Tokyo Japan
Publisher
Wiley
Subject
General Pharmacology, Toxicology and Pharmaceutics,Neurology
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1002/prp2.597
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1. Limited Brain Distribution of [3R,4R,5S]-4-Acetamido-5-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylate Phosphate (Ro 64-0802), a Pharmacologically Active Form of Oseltamivir, by Active Efflux across the Blood-Brain Barrier Mediated by Organic Anion Transporter 3 (Oat3/Slc22a8) and Multidrug Resistance-Associated Protein 4 (Mrp4/Abcc4)
2. Pharmacokinetics of oseltamivir: an oral antiviral for the treatment and prophylaxis of influenza in diverse populations
3. Pharmacokinetics of High-Dose Oseltamivir in Healthy Volunteers
4. Identification of GS 4104 as an Orally Bioavailable Prodrug of the Influenza Virus Neuraminidase Inhibitor GS 4071
5. Nonclinical Pharmacokinetics of Oseltamivir and Oseltamivir Carboxylate in the Central Nervous System
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