Resolution of Rac-Bambuterol via Diastereoisomeric Salt Formation with o-Chloromandelic Acid and Differences in the Enantiomers' Pharmacodynamical Effects in Guinea Pigs and Beagles

Author:

Wu Jie1,Liu Fei1,Wang Shanping1,Wang Hongjun1,Liu Qing1,Song Xinghan1,Li Junxiao1,Xu Ling2,Tan Wen1

Affiliation:

1. School of Bioscience and Bioengineering, South China University of Technology; Pre-Incubator for Innovative Drug and Medicine, South China University of Technology; Guangdong Provincial Key Laboratory of Fermentation and Enzyme Engineering; South China University of Technology; Guangzhou Guangdong China

2. Keypharma Biomedical Inc.; Songshan Lake Science & Technology Industry Park; Dongguan Guangdong China

Funder

Major Science and Technology Project

Publisher

Wiley

Subject

Organic Chemistry,Spectroscopy,Drug Discovery,Pharmacology,Catalysis,Analytical Chemistry

Reference27 articles.

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2. New lipophilic terbutaline ester prodrugs with long effect duration;Olsson;Pharm Res,1984

3. A placebo-controlled dose-finding study with bambuterol in elderly patients with asthma;Sitar;CHEST,1993

4. Bronchodilating effects of bambuterol on bronchoconstriction in guinea pigs;Xie;Zhong Guo Yao Li Xue Bao Acta Pharm Sin,1999

5. Vieira SE;Borges;Asthma in childhood: Drug Ther Rev Assoc Med Bras,2011

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