Enantiomeric 4-Acylamino-6-alkyloxy-2 Alkylthiopyrimidines As Potential A3Adenosine Receptor Antagonists: HPLC Chiral Resolution and Absolute Configuration Assignment by a Full Set of Chiroptical Spectroscopy

Author:

Rossi Daniela1,Nasti Rita1,Marra Annamaria1,Meneghini Silvia12,Mazzeo Giuseppe2,Longhi Giovanna2,Memo Maurizio2,Cosimelli Barbara3,Greco Giovanni3,Novellino Ettore3,Da Settimo Federico4,Martini Claudia4,Taliani Sabrina4,Abbate Sergio2,Collina Simona1

Affiliation:

1. Dipartimento di Scienze del Farmaco; Università di Pavia; Pavia Italy

2. Dipartimento di Medicina Molecolare e Traslazionale; Università di Brescia; Brescia Italy

3. Dipartimento di Farmacia; Università di Napoli “Federico II”; Napoli Italy

4. Dipartimento di Farmacia; Università di Pisa; Pisa Italy

Publisher

Wiley

Subject

Organic Chemistry,Spectroscopy,Drug Discovery,Pharmacology,Catalysis,Analytical Chemistry

Reference33 articles.

1. Recent developments in adenosine receptor ligands and their potential as novel drugs;Műller;Biochim Biophys Acta,1808

2. International union of basic and clinical pharmacology. LXXXI. Nomenclature and classification of adenosine receptors-an update;Fredholm;Pharmacol Rev,2011

3. Molecular cloning and characterization of the human A3 adenosine receptor;Salvatore;Proc Natl Acad Sci U S A,1993

4. Cloned adenosine A3 receptors: Pharmacological properties, species differences and receptor functions;Linden;Trends Pharmacol Sci,1994

5. Activation of the A3 adenosine receptor affects cell cycle progression and cell growth;Brambilla;Naunyn Schmiedeberg's Arch Pharmacol,2000

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