General Method of Synthesis for Naloxone, Naltrexone, Nalbuphone, and Nalbuphine by the Reaction of Grignard Reagents with an Oxazolidine Derived from Oxymorphone-Reference-Cited by-同舟云学术

General Method of Synthesis for Naloxone, Naltrexone, Nalbuphone, and Nalbuphine by the Reaction of Grignard Reagents with an Oxazolidine Derived from Oxymorphone

Published:2013-06-05 Issue:9 Volume:355 Page:1869-1873
ISSN:1615-4150
Container-title:Advanced Synthesis & Catalysis
language:en
Short-container-title:Adv. Synth. Catal.

Author:

Endoma-Arias Mary Ann A.,Cox D. Phillip,Hudlicky Tomas

Publisher

Wiley

Subject

General Chemistry

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/adsc.201300284/fullpdf

Reference45 articles.

1. The pharmacological treatment of opioid addiction—a clinical perspective

2. Synthesis of 14-Alkoxymorphinan Derivatives and Their Pharmacological Actions

3. UnexpectedN-Demethylation of Oxymorphone and OxycodoneN-Oxides Mediated by the Burgess Reagent: Direct Synthesis of Naltrexone, Naloxone, and Other Antagonists from Oxymorphone

Cited by 35 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Synthesis of nalbuphine and investigation of several mixtures of nalbuphine with other drugs for BALB/c mice anesthesia;Journal of Heterocyclic Chemistry;2023-06-18

2. Semi-synthesis of novel thebaine derivatives with low cytotoxicity and their antibacterial and antihemolytic properties;Medicinal Chemistry Research;2023-06-10

3. Semi-synthesis of Novel Thebaine Derivatives and their Anti-bacterial and Wound Healing Properties;2023-02-08

4. A study of the reactivity of cyclic aminomethylammonium mannich salts;Tetrahedron;2022-12

5. Sustainable Synthesis of Noroxymorphone via a Key Electrochemical N-Demethylation Step;ACS Sustainable Chemistry & Engineering;2022-06-29