Bioreactor Process Parameter Screening Utilizing a Plackett-Burman Design for a Model Monoclonal Antibody-Reference-Cited by-同舟云学术

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Bioreactor Process Parameter Screening Utilizing a Plackett-Burman Design for a Model Monoclonal Antibody

Published:2015-06 Issue:6 Volume:104 Page:1919-1928
ISSN:0022-3549
Container-title:Journal of Pharmaceutical Sciences
language:en
Short-container-title:Journal of Pharmaceutical Sciences

Author:

Agarabi Cyrus D.,Schiel John E.,Lute Scott C.,Chavez Brittany K.,Boyne Michael T.,Brorson Kurt A.,Khan Mansoora,Read Erik K.

Funder

National Institute for Standards and Technology

CDER Critical Path Program

Medical Counter Measure Initiative (MAK)

Publisher

Elsevier BV

Subject

Pharmaceutical Science

Reference49 articles.

1. Temperature shift as a process optimization step for the production of pro-urokinase by a recombinant Chinese hamster ovary cell line in high-density perfusion culture;Chen;J Biosci Bioeng,2004

2. Effect of dissolved-oxygen concentration on monoclonal-antibody production in hybridoma cell-cultures;Ogawa;J Ferment Bioeng,1992

3. Process parameter shifting: Part I. Effect of DOT, pH, and temperature on the performance of Epo-Fc expressing CHO cells cultivated in controlled batch bioreactors;Trummer;Biotechnol Bioeng,2006

4. Biological responses of hybridoma cells to hydrodynamic shear in an agitated bioreactor;Abu-Reesh;Enzyme Microb Technol,1991

5. Automated dynamic fed-batch process and media optimization for high productivity cell culture process development;Lu;Biotechnol Bioeng,2013

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