High glucose alters the secretome of mechanically stimulated osteocyte-like cells affecting osteoclast precursor recruitment and differentiation

Author:

Maycas Marta1,Portolés María Teresa2,Matesanz María Concepción2,Buendía Irene3,Linares Javier45,Feito María José45,Arcos Daniel45,Vallet-Regí María45,Plotkin Lilian I.678,Esbrit Pedro1,Gortázar Arancha R.3

Affiliation:

1. Laboratorio de Metabolismo Mineral y Óseo, Instituto de Investigación Sanitaria (IIS)-Fundación Jiménez Díaz; UAM; Madrid Spain

2. Facultad de Ciencias Químicas, Departamento de Bioquímica y Biología Molecular I, UCM; Instituto de Investigación Sanitaria San Carlos (IdISSC); Madrid Spain

3. IMMA- Facultad de Medicina; Universidad San Pablo CEU; Boadilla del Monte Madrid Spain

4. Facultad de Farmacia, Departamento de Química Inorgánica y Bioinorgánica; UCM; Madrid Spain

5. Instituto de Investigación Sanitaria Hospital 12 de Octubre (i + 12) CIBER-BBN; Madrid Spain

6. Department of Anatomy and Cell Biology; Indiana University School of Medicine; Indianapolis Indiana

7. Roudebush Veterans Administration Medical Center; Indianapolis Indiana

8. Indiana Center for Musculoskeletal Health; Indianapolis Indiana

Funder

Universidad San Pablo CEU

Ministerio de Ciencia e Innovación

Ministerio de Economía y Competitividad

Agening Network of Excellence

M.Maycas

Publisher

Wiley

Subject

Cell Biology,Clinical Biochemistry,Physiology

Reference52 articles.

1. Osteocyte apoptosis is induced by weightlessness in mice and precedes osteoclast recruitment and bone loss;Aguirre;Journal of Bone and Mineral Research,2006

2. Hyperglycemia reduces integrin subunits alpha v and alpha 5 on the surface of dermal fibroblasts contributing to deficient migration;Almeida;Molecular and Cellular Biochemistry,2016

3. Osteocyte-driven bone remodeling;Bellido;Calcified Tissue International,2014

4. Evidence that receptor activator of nuclear factor (NF)-kappaB ligand can suppress cell proliferation and induce apoptosis through activation of a NF-kappaB-independent and TRAF6-dependent mechanism;Bharti;The Journal of Biological Chemistry,2004

5. The impact of skeletal unloading on bone formation;Bikle;Gravitational and space biology bulletin: publication of the American Society for Gravitational and Space Biology,2003

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