Time‐to‐Event Endpoints in Imaging Biomarker Studies

Author:

Chen Ruizhe1ORCID,Wang Hao1

Affiliation:

1. The Sidney Kimmel Comprehensive Cancer Center, Division of Quantitative Sciences, Department of Oncology Johns Hopkins University School of Medicine Baltimore Maryland USA

Abstract

Time‐to‐event endpoints are widely used as measures of patients' well‐being and indicators of prognosis. In imaging‐based biomarker studies, there are increasingly more studies that focus on examining imaging biomarkers' prognostic or predictive utilities on those endpoints, whether in a trial or an observational study setting. In this educational review article, we briefly introduce some basic concepts of time‐to‐event endpoints and point out potential pitfalls in the context of imaging biomarker research in hope of improving radiologists' understanding of related subjects. Besides, we have included some review and discussions on the benefits of using time‐to‐event endpoints and considerations on selecting overall survival or progression‐free survival for primary analysis.Level of Evidence5Technical EfficacyStage 3

Publisher

Wiley

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