Left Atrial Phasic Function Impairment in Subacute and Chronic Pulmonary Embolism Patients With Different Degrees of Obstruction: An MRI Feature Tracking Study

Abstract

BackgroundThe alteration of left atrial (LA) phasic function in subacute and chronic pulmonary embolism (PE) patients is unclear.PurposeTo investigate LA phasic strain and LA‐right ventricular (RV) interaction in subacute and chronic PE patients with different degrees of obstruction by MRI‐feature tracking (MRI‐FT).Study TypeRetrospective.PopulationOne hundred three PE patients (54 subacute [2 weeks to 3 months after initial symptoms], 49 chronic [>3 months after initial symptoms]) and 80 controls.Field Strength/Sequence3.0 T/balanced steady state free precession sequence.AssessmentPatients were divided into mild (pulmonary artery obstruction index [PAOI] < 30%, N = 57), moderate (30% ≤ PAOI < 50%, N = 27), and severe (50% ≥ PAOI, N = 19) PE subgroups. LA reservoir, conduit, and active pump longitudinal strains (εs, εe, and εa) and strain rates (SRs, SRe, and SRa) and biventricular global strains were measured. Determinants of LA strains were investigated.Statistical TestsANOVA, t‐tests, Mann–Whitney U tests, linear regression. P < 0.05 was considered statistically significant.ResultsFor both subacute and chronic PE patients, LA reservoir, conduit, and active pump strains and strain rates were significantly lower than in controls. However, there were no significant differences in LA strains between patients with subacute and chronic PE (P = 0.933, 0.625, and 0.630 for εs, εe, and εa). The severe PE subgroup had significantly higher εa and SRa than the mild and moderate PE subgroups. LA strains were significantly correlated with RV diameter and biventricular strains, and RV diameter (β = −6.836, −4.084, and −1.899 for εs, εe, and εa) was independently associated with LA strains after adjustment for other factors (R2 = 0.627, 0.536, and 0.437 for εs, εe, and εa).Data ConclusionLA phasic function evaluated by MRI‐FT was significantly impaired in subacute and chronic PE patients, and LA active pump function in the severe PE subgroup was higher than that in the mild and moderate PE subgroups. The independent association between RV diameter and LA strains demonstrates that RV diameter may be an important indicator for monitoring LA dysfunction in PE patients.Evidence Level3Technical EfficacyStage 3