A Useful and Sustainable Role for N‐of‐1 Trials in the Healthcare Ecosystem-Reference-Cited by-同舟云学术

A Useful and Sustainable Role for N‐of‐1 Trials in the Healthcare Ecosystem

Published:2021-10-20 Issue: Volume: Page:
ISSN:0009-9236
Container-title:Clinical Pharmacology & Therapeutics
language:en
Short-container-title:Clin Pharmacol Ther

Author:

Selker Harry P.¹²,Cohen Theodora¹²,D’Agostino Ralph B.³⁴,Dere Willard H.⁵⁶,Ghaemi S. Nassir⁷⁸,Honig Peter K.⁹,Kaitin Kenneth I.¹⁰,Kaplan Heather C.¹¹¹²,Kravitz Richard L.¹³,Larholt Kay¹⁴,McElwee Newell E.¹⁵,Oye Kenneth A.¹⁶¹⁷,Palm Marisha E.¹²,Perfetto Eleanor¹⁸¹⁹,Ramanathan Chandra²⁰,Schmid Christopher H.²¹,Seyfert‐Margolis Vicki²²,Trusheim Mark²³,Eichler Hans‐Georg²⁴²⁵

Affiliation:

1. Tufts Medical Center Tufts Clinical and Translational Science Institute Boston Massachusetts USA

2. Tufts Medical Center Institute for Clinical Research and Health Policy Studies Boston Massachusetts USA

3. Department of Mathematics and Statistics Boston University Boston Massachusetts USA

4. Baim Institute for Clinical Research Boston Massachusetts USA

5. Department of Internal Medicine Utah Center for Clinical and Translational Science University of Utah Salt Lake City Utah USA

6. University of Utah School of Medicine Salt Lake City Utah USA

7. Psychiatry Tufts University School of Medicine Boston Massachusetts USA

8. Psychiatry Harvard Medical School Boston Massachusetts USA

9. Pfizer Collegeville Pennsylvania USA

10. Tufts Center for the Study of Drug Development Tufts University Boston Massachusetts USA

11. Cincinnati Children’s Hospital Medical Center Cincinnati Ohio USA

12. Perinatal Institute Cincinnati Children’s Hospital Medical Center Cincinnati Ohio USA

13. Department of Internal Medicine University of California, Davis Davis California USA

14. Center for Biomedical Innovation Massachusetts Institute of Technology Cambridge Massachusetts USA

15. Health Economics and Outcomes Research Boehringer Ingelheim Pharmaceuticals, Inc Ridgefield Connecticut USA

16. Department of Political Science Massachusetts Institute of Technology Cambridge Massachusetts USA

17. Center for Biomedical Innovation Cambridge Massachusetts USA

18. Department of Pharmaceutical Health Services Research University of Maryland School of Pharmacy Baltimore Maryland USA

19. National Health Council Washington District of Columbia USA

20. East Coast Innovation Center Bayer, Cambridge Massachusetts USA

21. Department of Biostatistics Brown University Providence Rhode Island USA

22. My Own Med Inc. Bethesda Maryland USA

23. Sloan School of Management Massachusetts Institute of Technology Cambridge Massachusetts USA

24. Regulatory Science and Innovation Task Force European Medicines Agency Amsterdam The Netherlands

25. Medical University of Vienna Vienna Austria

Funder

National Institutes of Health

National Center for Advancing Translational Sciences

Johns Hopkins University

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cpt.2425

Reference32 articles.

1. Effect of mobile device–supported single‐patient multi‐crossover trials on treatment of chronic musculoskeletal pain: a randomized clinical trial;Kravitz R.L.;JAMA Intern. Med.,2018

2. Lessons learned combining N‐of‐1 trials to assess fibromyalgia therapies;Zucker D.R.;J. Rheumatol.,2006

3. Theophylline for irreversible chronic airflow limitation: a randomized study comparing n of 1 trials to standard practice;Mahon J.L.;Chest,1999

4. Randomized clinical trials in single patients during a 2‐year period;Larson E.B.;JAMA,1993

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