Changes in self‐ and study partner–perceived cognitive functioning in relation to amyloid status and future clinical progression: Findings from the SCIENCe project

Author:

Dubbelman Mark A.12,Sikkes Sietske A. M.123,Ebenau Jarith L.12,van Leeuwenstijn Mardou S. S. A.12,Kroeze Lior A.12,Trieu Calvin12,van Berckel Bart N. M.24,Teunissen Charlotte E.25,van Harten Argonde C.12,van der Flier Wiesje M.126

Affiliation:

1. Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam Amsterdam UMC location VUmc Amsterdam the Netherlands

2. Amsterdam Neuroscience Amsterdam the Netherlands

3. Faculty of Behavioural and Movement Sciences, Clinical Developmental Psychology & Clinical Neuropsychology Vrije Universiteit Amsterdam Amsterdam the Netherlands

4. Department of Radiology and Nuclear Medicine, Amsterdam Neuroscience, Vrije Universiteit Amsterdam Amsterdam UMC Amsterdam the Netherlands

5. Neurochemistry Laboratory, Department of Clinical Chemistry, Amsterdam Neuroscience, Amsterdam UMC Vrije Universiteit Amsterdam Amsterdam the Netherlands

6. Department of Epidemiology and Data Science, Vrije Universiteit Amsterdam Amsterdam UMC location VUmc Amsterdam the Netherlands

Abstract

AbstractIntroductionWe investigated changes in self‐ and study partner–reported self‐perceived cognitive decline in relation to amyloid pathology and clinical progression, in a sample of cognitively normal individuals.MethodsA total of 404 participants (63 ± 9 years, 44% female) and their study partners completed the Cognitive Change Index (CCI) yearly (0.7–6.8 follow‐up years; n visits = 1436). Baseline and longitudinal associations between (change in) CCI scores, amyloid, and clinical progression were modeled in linear mixed models and Cox regressions.ResultsCCI–study partner scores of amyloid‐positive individuals increased over time (B = 1.79, 95% confidence interval [CI] = [0.51, 3.06]), while CCI–self scores remained stable (B = −0.45, 95% CI = [−1.77, 0.87]). Ten‐point higher baseline CCI–study partner (hazard ratio [HR] = 1.75, 95% CI = [1.30, 2.36]) and CCI–self scores (HR = 1.90, 95% CI = [1.40, 2.58]) were associated with an approximately 2‐fold increased risk of progression to mild cognitive impairment or dementia.DiscussionStudy partner–reported but not self‐perceived complaints increase over time in amyloid‐positive individuals, supporting the value of longitudinal study partner report, even in initially cognitively normal individuals.

Publisher

Wiley

Subject

Psychiatry and Mental health,Cellular and Molecular Neuroscience,Geriatrics and Gerontology,Neurology (clinical),Developmental Neuroscience,Health Policy,Epidemiology

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Longitudinal Trajectories of the Cognitive Function Index in the A4 Study;The Journal of Prevention of Alzheimer's Disease;2024

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