Application of bioreactor design principles and multivariate analysis for development of cell culture scale down models

Author:

Tescione Lia1,Lambropoulos James1,Paranandi Madhava Ram1,Makagiansar Helena1,Ryll Thomas1

Affiliation:

1. Biogen Idec, Cell Culture Development; 14 Cambridge Center Cambridge Massachusetts 02142

Publisher

Wiley

Subject

Applied Microbiology and Biotechnology,Bioengineering,Biotechnology

Reference41 articles.

1. Designing in quality: Approaches to defining the design space for a monoclonal antibody process;Banerjee;BioPharm Int,2010

2. Gas holdup in pneumatic reactors;Chisti;Chem Eng J,1988

3. An integrated approach to optimization of Escherichia coli fermentations using historical data;Coleman;Biotechnol Bioeng,2003

4. Effects of CO2 and osmolality on hybridoma cells: Growth, metabolism, and monoclonal antibody production;deZengotita;Cytotechnology,1998

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