Quantitative analysis of the farnesyl transferase inhibitor lonafarnib (Sarasar™, SCH66336) in human plasma using high-performance liquid chromatography coupled with tandem mass spectrometry-Reference-Cited by-同舟云学术

Quantitative analysis of the farnesyl transferase inhibitor lonafarnib (Sarasar™, SCH66336) in human plasma using high-performance liquid chromatography coupled with tandem mass spectrometry

Published:2005 Issue:15 Volume:19 Page:2187-2192
ISSN:0951-4198
Container-title:Rapid Communications in Mass Spectrometry
language:en
Short-container-title:Rapid Commun. Mass Spectrom.

Author:

Appels Natalie M. G. M.,van Maanen Maria J.,Rosing Hilde,Schellens Jan H. M.,Beijnen Jos H.

Publisher

Wiley

Subject

Organic Chemistry,Spectroscopy,Analytical Chemistry

Reference10 articles.

1. (+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]- pyridin-11(R)-yl)-1-piperidinyl]-2-oxo-ethyl]-1-piperidinecarboxamide (SCH-66336): A Very Potent Farnesyl Protein Transferase Inhibitor as a Novel Antitumor Agent

2. Isoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activity.

3. Farnesyl Protein Transferase Inhibition: A Novel Approach to Anti-tumor

4. Activity of the farnesyl protein transferase inhibitor SCH66336 against BCR/ABL-induced murine leukemia and primary cells from patients with chronic myeloid leukemia

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