Structural and Conformational Aspects of Equatorial and Axial Trifluoromethyl, Difluoromethyl, and Monofluoromethyl Groups
Author:
Affiliation:
1. ETH Zürich; Laboratorium für Organische Chemie; Vladimir-Prelog-Weg 3 8093 Zürich Switzerland
2. F. Hoffmann-La Roche AG; Pharmaceutical Research & Early Development; Roche Innovation Center Basel; Grenzacherstrasse 124 4070 Basel Switzerland
Funder
ETH
F. Hoffmann-La Roche
Publisher
Wiley
Subject
General Chemistry,Catalysis,Organic Chemistry
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1002/chem.201602643/fullpdf
Reference44 articles.
1. An Extended Table of Hammett Substitutent Constants Based on the Ionization of Substituted Benzoic Acids
2. Predicting and Tuning Physicochemical Properties in Lead Optimization: Amine Basicities
3. Fluorine substituent effects (on bioactivity)
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