One-Step Synthetic Access to Isosteric and Potent Anticancer Nitrogen Heterocycles with the Benzo[c]phenanthridine Scaffold-Reference-Cited by-同舟云学术

One-Step Synthetic Access to Isosteric and Potent Anticancer Nitrogen Heterocycles with the Benzo[c]phenanthridine Scaffold

Published:2016-05-06 Issue:24 Volume:22 Page:8301-8308
ISSN:0947-6539
Container-title:Chemistry - A European Journal
language:en
Short-container-title:Chem. Eur. J.

Author:

Steinhauer Tamara N.¹,Girreser Ulrich¹,Meier Christopher¹,Cushman Mark²,Clement Bernd¹

Affiliation:

1. Pharmazeutisches Institut; Lehrstuhl für Pharmazeutische Chemie; Universität Kiel; Gutenbergstrasse 76 24118 Kiel Germany), Fax

2. Department of Medicinal Chemistry and Molecular Pharmacology; College of Pharmacy and; The Purdue Center for Cancer Research; Purdue University; West Lafayette Indiana 47907 USA

Publisher

Wiley

Subject

General Chemistry,Catalysis,Organic Chemistry

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4. The antileukemic alkaloid fagaronine is an inhibitor of DNA topoisomerases I and II

5. Inhibition of topoisomerase I function by nitidine and fagaronine

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