New Cathepsin Inhibitors to Explore the Fluorophilic Properties of the S 2 Pocket of Cathepsin B: Design, Synthesis, and Biological Evaluation-Reference-Cited by-同舟云学术

New Cathepsin Inhibitors to Explore the Fluorophilic Properties of the S 2 Pocket of Cathepsin B: Design, Synthesis, and Biological Evaluation

Published:2011-03-30 Issue:19 Volume:17 Page:5256-5260
ISSN:0947-6539
Container-title:Chemistry – A European Journal
language:en
Short-container-title:Chem. Eur. J.

Author:

Fustero Santos¹²,Rodrigo Vanessa²,Sánchez‐Roselló María²,del Pozo Carlos¹,Timoneda Joaquín³,Frizler Maxim⁴⁵,Sisay Mihiret T.⁴⁶,Bajorath Jürgen⁶,Calle Luis P.⁷,Cañada F. Javier⁷,Jiménez‐Barbero Jesús⁷,Gütschow Michael⁴⁵

Affiliation:

1. Departamento de Química Orgánica, Universidad de Valencia, 46100 Burjassot (Spain), Fax: (+34) 963‐544‐939

2. Laboratorio de Moléculas Orgánicas, Centro de Investigación Príncipe Felipe, 46012 Valencia (Spain)

3. Departamento de Bioquímica y Biología Molecular, Universidad de Valencia, 46100 Burjassot (Spain)

4. Pharmaceutical Institute, Pharmaceutical Chemistry I, University of Bonn, 53121 Bonn (Germany), Fax: (+49) 228‐732567

5. NRW International Graduate Research School Biotech‐Pharma, 53105 Bonn (Germany)

6. Department of Life Science Informatics, B‐IT, University of Bonn, 53113 Bonn (Germany)

7. Chemical and Physical Biology, Centro de Investigaciones Biológicas, CSIC, 28040 Madrid (Spain), Fax: (+34) 915‐360‐432

Publisher

Wiley

Subject

General Chemistry,Catalysis,Organic Chemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/chem.201100113

Reference26 articles.

1. Emerging Roles of Cysteine Cathepsins in Disease and their Potential as Drug Targets

2. multifunctional enzymes in cancer

3. Direct Measurement of Cathepsin B Activity in the Cytosol of Apoptotic Cells by an Activity-Based Probe

4. Inhibitors of Cathepsin B Improve Memory and Reduce β-Amyloid in Transgenic Alzheimer Disease Mice Expressing the Wild-type, but Not the Swedish Mutant, β-Secretase Site of the Amyloid Precursor Protein

5. Peptidomimetic Inhibitors of Cathepsin K

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