Reaction Kinetics Direct a Rational Synthesis of an HIV-1 Inactivator of Nucleocapsid Protein 7 and Provide Mechanistic Insight into Cellular Metabolism and Antiviral Activity

Author:

Nikolayevskiy Herman1,Scerba Michael T.1,Deschamps Jeffrey R.2,Appella Daniel H.1ORCID

Affiliation:

1. Synthetic Bioactive Molecules Section, Laboratory of, Bioorganic Chemistry (LBC), National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); National Institutes of, Health (NIH); 8 Center Drive, Room 404 Bethesda MD 20892 USA

2. Naval Research Laboratory, Code 6910; 4555 Overlook Ave. SW Washington D.C. 20375 USA

Funder

National Institutes of Health

National Institute of Diabetes and Digestive and Kidney Diseases

Publisher

Wiley

Subject

General Chemistry,Catalysis,Organic Chemistry

Reference34 articles.

1. https://www.fda.gov/forpatients/illness/hivaids/treatment/ucm118915.htm

2. http://www.unaids.org/sites/default/files/media_asset/global-AIDS-update-2016_en.pdf

3. Contemporary costs of HIV healthcare in the HAART era

4. Current state and limitations of daily oral therapy for treatment

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