Discovery, Total Synthesis and Key Structural Elements for the Immunosuppressive Activity of Cocosolide, a Symmetrical Glycosylated Macrolide Dimer from Marine Cyanobacteria

Author:

Gunasekera Sarath P.1,Li Yang2,Ratnayake Ranjala3,Luo Danmeng3,Lo Jeannette4,Reibenspies Joseph H.5,Xu Zhengshuang2,Clare-Salzler Michael J.4,Ye Tao2,Paul Valerie J.1,Luesch Hendrik3

Affiliation:

1. Smithsonian Marine Station; 701 Seaway Drive Fort Pierce Florida 34949 USA

2. Laboratory of Chemical Genomics; School of Chemical Biology and Biotechnology; Shenzhen Graduate School of Peking University; Shenzhen 518055 P.R. China

3. Department of Medicinal Chemistry and Center for Natural Products; Drug Discovery and Development (CNPD3); University of Florida; Gainesville Florida 32610 USA

4. Department of Pathology, Immunology and Laboratory Medicine; University of Florida; Gainesville Florida 32610 USA

5. Department of Chemistry; Texas A & M University; College Station Texas 77843 USA

Funder

NIH

Shenzhen Peacock Plan

Publisher

Wiley

Subject

General Chemistry,Catalysis,Organic Chemistry

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