Evaluation of 1,2,3‐Triazoles as Amide Bioisosteres In Cystic Fibrosis Transmembrane Conductance Regulator Modulators VX‐770 and VX‐809-Reference-Cited by-同舟云学术

Evaluation of 1,2,3‐Triazoles as Amide Bioisosteres In Cystic Fibrosis Transmembrane Conductance Regulator Modulators VX‐770 and VX‐809

Published:2019-02-11 Issue:14 Volume:25 Page:3662-3674
ISSN:0947-6539
Container-title:Chemistry – A European Journal
language:en
Short-container-title:Chem. Eur. J.

Author:

Doiron Jake E.¹,Le Christina A.²,Ody Britton K.¹,Brace Jonathon B.¹,Post Savannah J.¹,Thacker Nathan L.¹,Hill Harrison M.¹,Breton Gary W.¹,Mulder Matthew J.³,Chang Sichen³,Bridges Thomas M.³,Tang Liping⁴⁵,Wang Wei⁵⁶,Rowe Steven M.⁴⁵⁶^ORCID,Aller Stephen G.²^ORCID,Turlington Mark¹^ORCID

Affiliation:

1. Department of Chemistry and BiochemistryBerry College Mount Berry Georgia 30165 USA

2. Department of Pharmacology and ToxicologyUniversity of Alabama at Birmingham Birmingham Alabama 35205 USA

3. Vanderbilt Center for Neuroscience Drug Discovery Nashville Tennessee 37232 USA

4. Departments of Medicine and PediatricsUniversity of Alabama at Birmingham Birmingham Alabama 35205 USA

5. Gregory Fleming James Cystic Fibrosis Research CenterUniversity of Alabama at Birmingham Birmingham Alabama 35205 USA

6. Department of Cell, Development, and Integrative BiologyUniversity of Alabama at Birmingham Birmingham Alabama 35205 USA

Funder

Cystic Fibrosis Foundation

National Institutes of Health

Publisher

Wiley

Subject

General Chemistry,Catalysis,Organic Chemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/chem.201805919

Reference51 articles.

1. Copper-catalyzed azide–alkyne cycloaddition (CuAAC) and beyond: new reactivity of copper(i) acetylides

2. The 1,2,3-triazole ring as a bioisostere in medicinal chemistry

3. The impact of click chemistry in medicinal chemistry

4. Click chemistry reactions in medicinal chemistry: Applications of the 1,3-dipolar cycloaddition between azides and alkynes

5. The growing impact of click chemistry on drug discovery

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