Synthesis and Superpotent Anticancer Activity of Tubulysins Carrying Non-hydrolysable N-Substituents on Tubuvaline-Reference-Cited by-同舟云学术

Synthesis and Superpotent Anticancer Activity of Tubulysins Carrying Non-hydrolysable N-Substituents on Tubuvaline

Published:2017-04-12 Issue:24 Volume:23 Page:5842-5850
ISSN:0947-6539
Container-title:Chemistry - A European Journal
language:en
Short-container-title:Chem. Eur. J.

Author:

Sani Monica¹²,Lazzari Paolo¹,Folini Marco³,Spiga Marco¹,Zuco Valentina³,De Cesare Michelandrea³,Manca Ilaria⁴,Dall'Angelo Sergio⁵,Frigerio Massimo⁶,Usai Igor¹,Testa Andrea⁵,Zaffaroni Nadia³,Zanda Matteo⁵²^ORCID

Affiliation:

1. KemoTech Srl, Edificio 3; Località Piscinamanna; 09010 Pula (CA Italy

2. C.N.R.; Istituto di Chimica del Riconoscimento Molecolare; Via Mancinelli 7 20131 Milano (MI) Italy

3. Fondazione IRCCS Istituto Nazionale dei Tumori; Farmacologia Molecolare; Via Amadeo 42 20133 Milano (MI) Italy

4. C.N.R. Istituto di Farmacologia Traslazionale; UOS di Cagliari, Edificio 5, Località Piscinamanna; 09010 Pula (CA) Italy

5. Kosterlitz Centre for Therapeutics; Institute of Medical Sciences; School of Medicine, Medical Sciences and Nutrition; University of Aberdeen, Foresterhill; Aberdeen AB25 2ZD Scotland UK

6. Dipartimento di Chimica, Materiali e Ingegneria Chimica; Politecnico di Milano; Via Mancinelli 7 20131 Milano (MI Italy

Publisher

Wiley

Subject

General Chemistry,Catalysis,Organic Chemistry

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/chem.201700874/fullpdf

Reference53 articles.

1. Tubulysins, New Cytostatic Peptides from Myxobacteria Acting on Microtubuli. Production, Isolation, Physico-chemical and Biological Properties.

2. Synthesis and Biological Evaluation of Pretubulysin and Derivatives

3. Isolation, Crystal and Solution Structure Determination, and Biosynthesis of Tubulysins—Powerful Inhibitors of Tubulin Polymerization from Myxobacteria

4. Isolation, Crystal and Solution Structure Determination, and Biosynthesis of Tubulysins—Powerful Inhibitors of Tubulin Polymerization from Myxobacteria

5. Design, Synthesis, and Biological Properties of Highly Potent Tubulysin D Analogues

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