Stereoselective Preparation of (E)-Configured 1,2-Disubstituted Propenes from Two Aldehydes by a Two-Carbon Stitching Strategy: Convergent Synthesis of 18,21-Diisopropyl-Geldanamycin Hydroquinone and Its C7 Epimer-Reference-Cited by-同舟云学术

Stereoselective Preparation of (E)-Configured 1,2-Disubstituted Propenes from Two Aldehydes by a Two-Carbon Stitching Strategy: Convergent Synthesis of 18,21-Diisopropyl-Geldanamycin Hydroquinone and Its C7 Epimer

Published:2012-07-16 Issue:33 Volume:18 Page:10382-10392
ISSN:0947-6539
Container-title:Chemistry - A European Journal
language:en
Short-container-title:Chem. Eur. J.

Author:

Hampel Thomas,Neubauer Thomas,van Leeuwen Thomas,Bach Thorsten

Publisher

Wiley

Subject

General Chemistry,Catalysis,Organic Chemistry

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/chem.201201600/fullpdf

Reference137 articles.

1. Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation.

2. Crystal Structure of an Hsp90–Geldanamycin Complex: Targeting of a Protein Chaperone by an Antitumor Agent

3. Structural Basis for Inhibition of the Hsp90 Molecular Chaperone by the Antitumor Antibiotics Radicicol and Geldanamycin

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