Studies of Glutathione Transferase P1‐1 Bound to a Platinum(IV)‐Based Anticancer Compound Reveal the Molecular Basis of Its Activation

Author:

Parker Lorien J.12,Italiano Louis C.12,Morton Craig J.1,Hancock Nancy C.1,Ascher David B.1,Aitken Jade B.3,Harris Hugh H.4,Campomanes Pablo5,Rothlisberger Ursula5,De Luca Anastasia6,Lo Bello Mario6,Ang Wee Han7,Dyson Paul J.5,Parker Michael W.12

Affiliation:

1. Biota Structural Biology Laboratory, St. Vincent's Institute of Medical Research, 41 Victoria Parade, Fitzroy, Victoria 3065 (Australia), Fax: (+61) 3‐9416‐2676

2. Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, 30 Flemington Road, Parkville, Victoria 3010 (Australia)

3. School of Chemistry, The University of Sydney, New South Wales 2006 (Australia)

4. School of Chemistry and Physics, University of Adelaide, South Australia 5005 (Australia)

5. Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne (Switzerland)

6. Department of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica 1, Rome 00133 (Italy)

7. Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543 (Singapore)

Publisher

Wiley

Subject

General Chemistry,Catalysis,Organic Chemistry

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