Synthesis of Potent and Selective HDAC6 Inhibitors Bearing a Cyclohexane- or Cycloheptane-Annulated 1,5-Benzothiazepine Scaffold-Reference-Cited by-同舟云学术

Synthesis of Potent and Selective HDAC6 Inhibitors Bearing a Cyclohexane- or Cycloheptane-Annulated 1,5-Benzothiazepine Scaffold

Published:2016-11-30 Issue:1 Volume:23 Page:128-136
ISSN:0947-6539
Container-title:Chemistry - A European Journal
language:en
Short-container-title:Chem. Eur. J.

Author:

De Vreese Rob¹,Galle Lisa¹,Depetter Yves¹,Franceus Jorick²,Desmet Tom²,Van Hecke Kristof³,Benoy Veronick⁴,Van Den Bosch Ludo⁴,D'hooghe Matthias¹

Affiliation:

1. SynBioC Research Group; Faculty of Bioscience Engineering; Ghent University; Coupure Links 653 9000 Ghent Belgium

2. Centre for Industrial Biotechnology and Biocatalysis; Faculty of Bioscience Engineering; Ghent University; Coupure Links 653 9000 Ghent Belgium

3. XStruct, Department of Inorganic and Physical Chemistry; Faculty of Sciences; Ghent University; Krijgslaan 281-S3 9000 Ghent Belgium

4. University of Leuven; Department of Neurosciences, Experimental Neurology, VIB-Vesalius Research Center, Laboratory of Neurobiology; 3000 Leuven Belgium

Publisher

Wiley

Subject

General Chemistry,Catalysis,Organic Chemistry

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/chem.201604167/fullpdf

Reference50 articles.

1. Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions

2. Lysine Acetylation: Codified Crosstalk with Other Posttranslational Modifications

3. Acetylation and deacetylation of non-histone proteins

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