Chronic neurodegeneration induces type I interferon synthesis via STING, shaping microglial phenotype and accelerating disease progression-Reference-Cited by-同舟云学术

Chronic neurodegeneration induces type I interferon synthesis via STING, shaping microglial phenotype and accelerating disease progression

Published:2019-01-25 Issue:7 Volume:67 Page:1254-1276
ISSN:0894-1491
Container-title:Glia
language:en
Short-container-title:Glia

Author:

Nazmi Arshed¹,Field Robert H.¹,Griffin Eadaoin W.¹,Haugh Orla¹,Hennessy Edel¹,Cox Donal¹,Reis Renata¹,Tortorelli Lucas¹,Murray Carol L.¹,Lopez‐Rodriguez Ana Belen¹,Jin Lei²,Lavelle Ed C.¹,Dunne Aisling¹,Cunningham Colm¹^ORCID

Affiliation:

1. School of Biochemistry and ImmunologyTrinity College Institute of Neuroscience & Trinity Biomedical Sciences Institute, Trinity College Dublin Dublin Republic of Ireland

2. Department of Medicine, Division of Pulmonary, Critical Care and Sleep MedicineUniversity of Florida Gainesville Florida

Funder

National Institutes of Health

Wellcome Trust

Publisher

Wiley

Subject

Cellular and Molecular Neuroscience,Neurology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/glia.23592

Reference78 articles.

1. STING-mediated type-I interferons contribute to the neuroinflammatory process and detrimental effects following traumatic brain injury

2. Transgenic expression of IFN‐alpha in the central nervous system of mice protects against lethal neurotropic viral infection but induces inflammation and neurodegeneration;Akwa Y.;Journal of Immunology,1998

3. ACCELERATION OF SCRAPIE IN MICE BY TARGET-ORGAN TREATMENT WITH INTERFERON INDUCERS

4. Early induction of interferon-responsive mRNAs in Creutzfeldt-Jakob disease

5. Aging-induced type I interferon response at the choroid plexus negatively affects brain function

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