A Target‐Mediated Drug Disposition Model to Explain Nonlinear Pharmacokinetics of the 11β‐Hydroxysteroid Dehydrogenase Type 1 Inhibitor SPI‐62 in Healthy Adults
Author:
Affiliation:
1. Division of Pharmaceutics and Translational Therapeutics College of Pharmacy University of Iowa Iowa City Iowa USA
2. Sparrow Pharmaceuticals, Inc. Portland Oregon USA
Publisher
Wiley
Subject
Pharmacology (medical),Pharmacology
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1002/jcph.1925
Reference27 articles.
1. 11β-Hydroxysteroid Dehydrogenase Type 1: A Tissue-Specific Regulator of Glucocorticoid Response
2. Splanchnic Cortisol Production Occurs in Humans
3. Cushing's syndrome
4. Modern Management of Mild Autonomous Cortisol Secretion
5. 11β-Hydroxysteroid Dehydrogenase Types 1 and 2: An Important Pharmacokinetic Determinant for the Activity of Synthetic Mineralo- and Glucocorticoids
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