Link among <i>apolipoprotein E</i> E4, gait, and cognition in neurodegenerative diseases: ONDRI study-Reference-Cited by-同舟云学术

Link among apolipoprotein E E4, gait, and cognition in neurodegenerative diseases: ONDRI study

Published:2024-03-12 Issue:4 Volume:20 Page:2968-2979
ISSN:1552-5260
Container-title:Alzheimer's & Dementia
language:en
Short-container-title:Alzheimer's & Dementia

Author:

Sakurai Ryota¹²^ORCID,Pieruccini‐Faria Frederico²³^ORCID,Cornish Benjamin⁴^ORCID,Fraser Julia⁴,Binns Malcolm A.⁵^ORCID,Beaton Derek⁶^ORCID,Dilliott Allison Ann⁷^ORCID,Kwan Donna⁸^ORCID,Ramirez Joel⁹^ORCID,Tan Brian⁵^ORCID,Scott Christopher J. M.⁵,Sunderland Kelly M.⁵^ORCID,Tartaglia Carmela¹⁰¹¹^ORCID,Finger Elizabeth¹²^ORCID,Zinman Lorne¹³¹⁴^ORCID,Freedman Morris⁵¹⁴¹⁵^ORCID,McLaughlin Paula M.¹⁶^ORCID,Swartz Richard H.¹³¹⁴^ORCID,Symons Sean⁹^ORCID,Lang Anthony E.¹⁷^ORCID,Bartha Robert¹⁸^ORCID,Black Sandra E.⁹^ORCID,Masellis Mario⁹^ORCID,Hegele Robert A.¹⁹²⁰^ORCID,McIlroy William²¹^ORCID, ,Montero‐Odasso Manuel²²²²³^ORCID

Affiliation:

1. Research Team for Social Participation and Healthy Aging Tokyo Metropolitan Institute for Geriatrics and Gerontology Itabashi‐ku Tokyo Japan

2. Gait & Brain Lab, St. Joseph' Health Care London, Lawson Health Research, Western University, Division of Geriatric Medicine London Ontario Canada

3. Department of Medicine Division of Geriatric Medicine Parkwood Hospital Western University, Parkwood Institute London Ontario Canada

4. Neuroscience, Mobility and Balance Lab, Department of Kinesiology and Health Sciences University of Waterloo Waterloo Ontario Canada

5. Rotman Research Institute, Baycrest Health Sciences Toronto Ontario Canada

6. Data Science and Advanced Analytics, St. Michael's Hospital, Unity Health Toronto Toronto Ontario Canada

7. Department of Neurology and Neurosurgery Montreal Neurological Institute, McGill University Montréal Quebec Canada

8. Centre for Neuroscience Studies, Queen's University Kingston Ontario Canada

9. L.C. Campbell Cognitive Neurology Research Unit, Hurvitz Brain Sciences Program, Department of Medicine (Neurology) Sunnybrook Research Institute, Sunnybrook HSC, University of Toronto Toronto Ontario Canada

10. Krembil Brain Institute University Health Network Memory Clinic, Toronto Western Hospital Toronto Ontario Canada

11. Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto Toronto Ontario Canada

12. Department of Clinical Neurological Sciences Schulich School of Medicine and Dentistry, Western University London Ontario Canada

13. Sunnybrook Research Institute, Sunnybrook Health Sciences Centre Toronto Ontario Canada

14. Department of Medicine (Neurology) University of Toronto Toronto Ontario Canada

15. Division of Neurology Baycrest Health Sciences Toronto Ontario Canada

16. Halifax Clinical Psychology Residency Program Nova Scotia Health Authority Halifax Nova Scotia Canada

17. Division of Neurology Department of Medicine Edmond J Safra Program in Parkinson's Disease and Morton and Gloria Shulman Movement Disorders Clinic Toronto Western Hospital University of Toronto Toronto Ontario Canada

18. Department of Medical Biophysics Schulich School of Medicine and Dentistry, Robarts Research Institute, Western University London Ontario Canada

19. Schulich School of Medicine and Dentistry, Western University London Ontario Canada

20. Robarts Research Institute, Western University London Ontario Canada

21. Neuroscience, Mobility and Balance Laboratory, Department of Kinesiology and Health Sciences University of Waterloo Waterloo Ontario Canada

22. Gait and Brain Lab, Division of Geriatric Medicine and Lawson Health Research Institute Parkwood Institute, Western University London Ontario Canada

23. Division of Geriatric Medicine Department of Medicine Schulich School of Medicine and Dentistry, Western University, Parkwood Institute London Ontario Canada

Abstract

AbstractINTRODUCTIONApolipoprotein E E4 allele (APOE E4) and slow gait are independently associated with cognitive impairment and dementia. However, it is unknown whether their coexistence is associated with poorer cognitive performance and its underlying mechanism in neurodegenerative diseases.METHODSGait speed, APOE E4, cognition, and neuroimaging were assessed in 480 older adults with neurodegeneration. Participants were grouped by APOE E4 presence and slow gait. Mediation analyses were conducted to determine if brain structures could explain the link between these factors and cognitive performance.RESULTSAPOE E4 carriers with slow gait had the lowest global cognitive performance and smaller gray matter volumes compared to non‐APOE E4 carriers with normal gait. Coexistence of APOE E4 and slow gait best predicted global and domain‐specific poorer cognitive performances, mediated by smaller gray matter volume.DISCUSSIONGait slowness in APOE E4 carriers with neurodegenerative diseases may indicate extensive gray matter changes associated with poor cognition.Highlights

APOE E4 and slow gait are risk factors for cognitive decline in neurodegenerative diseases.

Slow gait and smaller gray matter volumes are associated, independently of APOE E4.

Worse cognition in APOE E4 carriers with slow gait is explained by smaller GM volume.

Gait slowness in APOE E4 carriers indicates poorer cognition‐related brain changes.

Funder

Centre for Addiction and Mental Health Foundation

London Health Sciences Foundation

Faculty of Health Sciences, Queen's University

Temerty Family Foundation

Publisher

Wiley

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