Systematic analysis of residual density suggests that a major limitation in well-refined X-ray structures of proteins is the omission of ordered solvent

Author:

Wang Jimin1

Affiliation:

1. Department of Molecular Biophysics and Biochemistry; Yale University; New Haven Connecticut 06520

Funder

National Institutes of Health

Publisher

Wiley

Subject

Molecular Biology,Biochemistry

Reference36 articles.

1. Why are protein crystallographic R-values so high?;Lattman;Proteins,1996

2. Why protein R-factors are so large: a self-consistent analysis;Vitkup;Proteins,2002

3. Foundations of residual-density analysis;Meindl;Acta Cryst A,2008

4. Crystal structure of E. coli HPII catalase variant;Wang;PDB Entry Released.,2015

5. Modulation of heme orientation and binding by a single residue in catalase HPII of Escherichia coli;Jha;Biochemistry,2011

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