Reduction of IL‐2 fragmentation during manufacturing of a novel immunocytokine by DoE process optimization-Reference-Cited by-同舟云学术

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Reduction of IL‐2 fragmentation during manufacturing of a novel immunocytokine by DoE process optimization

Published:2019-07-02 Issue:10 Volume:116 Page:2503-2513
ISSN:0006-3592
Container-title:Biotechnology and Bioengineering
language:en
Short-container-title:Biotechnology and Bioengineering

Author:

Schneider Alina¹^ORCID,Gorr Ingo H.¹²^ORCID,Larraillet Vincent³,Frensing Timo¹,Popp Oliver¹

Affiliation:

1. Pharma Research and Early Development, Cell Culture Research, Roche Innovation Center MunichRoche Diagnostics GmbH Munich Germany

2. Early Stage Bioprocess DevelopmentBoehringer Ingelheim Pharma GmbH & Co., KG Biberach an der Riss Germany

3. Pharma Research and Early Development, Biochemical and Analytical Research, Roche Innovation Center MunichRoche Diagnostics GmbH Munich Germany

Publisher

Wiley

Subject

Applied Microbiology and Biotechnology,Bioengineering,Biotechnology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/bit.27090

Reference40 articles.

1. Investigation of the interactions of critical scale-up parameters (pH, pO2 and pCO2) on CHO batch performance and critical quality attributes

2. Characterization and Optimization of Cell Seeding in Scaffolds by Factorial Design: Quality by Design Approach for Skeletal Tissue Engineering

3. Industrial choices for protein production by large-scale cell culture

4. β-Elimination and Peptide Bond Hydrolysis: Two Distinct Mechanisms of Human IgG1 Hinge Fragmentation upon Storage

5. Optimization of a Saccharomyces cerevisiae fermentation process for production of a therapeutic recombinant protein using a multivariate bayesian approach

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1. Intensified perfusion culture (IPC) reduced recombinant protein fragmentation;Biotechnology Progress;2023-11-24

2. Progress in fed-batch culture for recombinant protein production in CHO cells;Applied Microbiology and Biotechnology;2023-01-17

3. Kinetic modeling: A tool for temperature shift and feeding optimization in cell culture process development;Protein Expression and Purification;2022-10

4. Antibody-Based Targeting of Interferon-Beta-1a Mutein in HER2-Positive Cancer Enhances Antitumor Effects Through Immune Responses and Direct Cell Killing;Frontiers in Pharmacology;2021-01-08

5. Correlation between p16 and Interleukin-2 Gene Expression and Oral and Maxillofacial Wound Healing;Indian Journal of Pharmaceutical Sciences;2021

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