Prospective study of germline genetic testing in incident cases of pancreatic adenocarcinoma

Author:

Brand Randall1,Borazanci Erkut2,Speare Virginia3ORCID,Dudley Beth1ORCID,Karloski Eve1,Peters Mary Linton B.4ORCID,Stobie Lindsey4,Bahary Nathan1,Zeh Herbert5,Zureikat Amer5,Hogg Melissa5,Lee Kenneth5,Tsung Allan5,Rhee John1,Ohr James1,Sun Weijing6,Lee James1,Moser A. James4,DeLeonardis Kim4,Krejdovsky Jill4,Dalton Emily3,LaDuca Holly3,Dolinsky Jill3,Colvin Arlene2,Lim Cynthia2,Black Mary Helen3,Tung Nadine4

Affiliation:

1. Department of Medicine; University of Pittsburgh Medical Center; Pittsburgh Pennsylvania

2. HonorHealth; Scottsdale Arizona

3. Ambry Genetics; Aliso Viejo California

4. Beth Israel Deaconess Medical Center; Boston Massachusetts

5. Department of Surgery; University of Pittsburgh Medical Center; Pittsburgh Pennsylvania

6. Division of Medical Oncology; University of Kansas; Kansas City Kansas

Funder

Scottish Alliance for Geoscience, Environment and Society

Ambry Genetics provided administrative support for the study and genetic testing at no fee to the institution, patient or insurance

Publisher

Wiley

Subject

Cancer Research,Oncology

Reference31 articles.

1. National Cancer Institute Surveillance, Epidemiology, and End Results Program https://www.seer.cancer.gov 2017

2. Family history is a significant risk factor for pancreatic cancer: results from a systematic review and meta-analysis;Permuth-Wey;Fam Cancer.,2009

3. Whole genome sequencing defines the genetic heterogeneity of familial pancreatic cancer;Roberts;Cancer Discov.,2016

4. BRCA1, BRCA2, PALB2, and CDKN2A mutations in familial pancreatic cancer: a PACGENE study;Zhen;Genet Med.,2015

5. Genetic susceptibility to pancreatic cancer;Klein;Mol Carcinog.,2012

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