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U6 promoter-enhanced GlnUAG suppressor tRNA has higher suppression efficacy and can be stably expressed in 293 cells

  • Published:2013-02 Issue:2 Volume:15 Page:93-101
  • ISSN:1099-498X
  • Container-title:The Journal of Gene Medicine
  • language:en
  • Short-container-title:J Gene Med

Author:

Koukuntla Ramesh1,Ramsey William J.2,Young Won-Bin2,Link Charles J.

Affiliation:

1. Genetics, Cellular and Developmental Biology; Iowa State University; Ames; IA; USA

2. NewLink Genetics Corp.; Ames; IA; USA

Publisher

Wiley

Subject

Genetics (clinical),Drug Discovery,Genetics,Molecular Biology,Molecular Medicine

Reference51 articles.

1. A world in one dimension: Linus Pauling, Francis Crick and the central dogma of molecular biology;Strasser;Hist Philos Life Sci,2006

2. Eukaryotic start and stop translation sites;Cavener;Nucleic Acids Res,1991

3. Mutations to nonsense codons in human genetic disease: implications for gene therapy by nonsense suppressor tRNAs;Atkinson;Nucleic Acids Res,1994

4. Yeast super-suppressors are altered tRNAs capable of translating a nonsense codon in vitro;Capecchi;Cell,1975

5. The isolation of a suppressible nonsense mutant in mammalian cells;Capecchi;Cell,1977

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1. Suppressor tRNA in gene therapy;Science China Life Sciences;2024-06-24

2. Mechanisms and Delivery of tRNA Therapeutics;Chemical Reviews;2024-05-27

3. Transfer RNAs as dynamic and critical regulators of cancer progression;Nature Reviews Cancer;2023-10-09

4. Stops making sense – For the people?;Clinical and Translational Medicine;2023-05

5. AAV-delivered suppressor tRNA overcomes a nonsense mutation in mice;Nature;2022-03-23
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