Expressing antigen binding fragments with high titers in a targeted integration <scp>CHO</scp> host by optimizing expression vector gene copy numbers and position: A case study-Reference-Cited by-同舟云学术

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Expressing antigen binding fragments with high titers in a targeted integration CHO host by optimizing expression vector gene copy numbers and position: A case study

Published:2022-08-16 Issue:6 Volume:38 Page:
ISSN:8756-7938
Container-title:Biotechnology Progress
language:en
Short-container-title:Biotechnology Progress

Author:

Tang Danming¹²^ORCID,Gunson Jane¹,Tran Eric¹,Lam Cynthia¹,Shen Amy¹^ORCID,Snedecor Brad¹,Barnard Gavin¹,Misaghi Shahram¹^ORCID

Affiliation:

1. Cell Culture and Bioprocess Operations Department Genentech Inc. South San Francisco California USA

2. Protein Sciences, Proteologix US Inc., Redwood Shores California USA

Publisher

Wiley

Subject

Biotechnology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/btpr.3290

Reference28 articles.

1. The state-of-play and future of antibody therapeutics

2. Antibody fragments

3. Generating recombinant antibodies to the complete human proteome

4. Systematic screening of soluble expression of antibody fragments in the cytoplasm of E. coli

5. Development of a high yieldingE. coliperiplasmic expression system for the production of humanized Fab' fragments

Cited by 2 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Study on chromatin regulation patterns of expression vectors in the PhiC31 integration site;Epigenetics;2024-04-09

2. A Highly Efficient Workflow for Detecting and Identifying Sequence Variants in Therapeutic Proteins with a High Resolution LC-MS/MS Method;Molecules;2023-04-12

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