First pass intestinal and liver metabolism of paracetamol in a microfluidic platform coupled with a mathematical modeling as a means of evaluating ADME processes in humans-Reference-Cited by-同舟云学术

First pass intestinal and liver metabolism of paracetamol in a microfluidic platform coupled with a mathematical modeling as a means of evaluating ADME processes in humans

Published:2014-06-24 Issue:10 Volume:111 Page:2027-2040
ISSN:0006-3592
Container-title:Biotechnology and Bioengineering
language:en
Short-container-title:Biotechnol. Bioeng.

Author:

Prot Jean Matthieu¹,Maciel Luis¹,Bricks Thibault¹,Merlier Franck²,Cotton Jérôme³,Paullier Patrick¹,Bois Fréderic Yves⁴⁵,Leclerc Eric¹

Affiliation:

1. CNRS UMR 7338; Laboratoire de Biomécanique et Bio ingénierie, Université de Technologie de Compiègne; Compiegne Picardie France

2. CNRS EA; Laboratoire de Génie enzymatique et Cellulaire, Université de Technologie de Compiègne; Compiegne Picardie France

3. Profilomic; Boulogne-Billancourt Ile de France France

4. INERIS; Unité Modèles pour la toxicologie (METO); Verneuil-en-Halatte Picardie France

5. Chaire de toxicologie prédictive; Université de Technologie de Compiègne; Compiegne Picardie France

Funder

Fondation pour la Recherche et l'Innovation” from the Université de Technologie in Compiègne (ToxOnChip project)

ERASMUS exchange program

189-post Grenelle program via the Activism project

Publisher

Wiley

Subject

Applied Microbiology and Biotechnology,Bioengineering,Biotechnology

Reference52 articles.

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3. Evaluation of a liver microfluidic biochip to predict in vivo clearances of seven drugs in rats;Baudoin;J Pharm Sci,2014

4. Utility of hepatocytes to model species differences in the metabolism of loxtidine and to predict pharmacokinetic parameters in rat, dog and man;Bayliss;Xenobiotica,1999

5. The integration of data on physico-chemical properties, in vitro-derived toxicity data and physiologically based kinetic and dynamic as modelling a tool in hazard and risk assessment. A commentary;Blaauboer;Toxicol Lett,2003

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