A first-in-human phase I, multicenter, open-label, dose-escalation study of the oral RAF/VEGFR-2 inhibitor (RAF265) in locally advanced or metastatic melanoma independent from BRAF mutation status

Author:

Izar Benjamin123ORCID,Sharfman William4,Hodi F. Stephen5,Lawrence Donald6,Flaherty Keith T.67,Amaravadi Ravi7,Kim Kevin B.8,Puzanov Igor9,Sosman Jeffrey9,Dummer Reinhard10,Goldinger Simone M.10,Lam Lyhping11,Kakar Shefali12,Tang Zhongwen12,Krieter Oliver13,McDermott David F.1,Atkins Michael B.114

Affiliation:

1. Beth Israel Deaconess Medical Center; Boston Massachusetts

2. Center for Cancer Precision Medicine/Dana-Farber Cancer Institute and the Broad Institute; Boston Massachusetts

3. Broad Institute of MIT and Harvard; Cambridge Massachusetts

4. Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; Baltimore Maryland

5. Dana Farber Cancer Institute; Boston Massachusetts

6. Massachusetts General Hospital; Boston Massachusetts

7. Abramson Cancer Center of the University of Pennsylvania; Philadelphia Pennsylvania

8. California Pacific Medical Center Research Institute; San Francisco California

9. Vanderbilt-Ingram Cancer Center; Vanderbilt Tennessee

10. University Hospital; Zurich Switzerland

11. Novartis Institutes for BioMedical Research; Inc.; Cambridge Massachusetts

12. Novartis Pharmaceuticals Corporation; East Hanover New Jersey

13. Novartis Pharma AG; Basel Switzerland

14. Georgetown-Lombardi Comprehensive Cancer Center; Washington District of Columbia

Funder

Novartis

Publisher

Wiley

Subject

Cancer Research,Radiology, Nuclear Medicine and imaging,Oncology

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