TNF-α promotes osteoclastogenesis through JNK signaling-dependent induction of Semaphorin3D expression in estrogen-deficiency induced osteoporosis

Author:

Sang Chenglin12,Zhang Jiefeng3,Zhang Yongxian12,Chen Fangjing12,Cao Xuecheng12,Guo Lei4ORCID

Affiliation:

1. Department of Orthopaedics; Second Military Medical University's Jinan Clinical Medicine College; Jinan China

2. Department of Orthaopedics; General Hospital of Jinan Military Command; Jinan Shandong P. R. China

3. Taian City Central Hospital; Department of Traumatology; Taian City Shandong P. R. China

4. Shanghai Key Laboratory for Bone and Joint Diseases, Shanghai Institute of Orthopaedics and Traumatology, Shanghai Ruijin Hospital; Shanghai Jiaotong University School of Medicine; Shanghai P. R. China

Funder

National Natural Science Foundation of China

Shanghai Municipal Education Commission

Publisher

Wiley

Subject

Cell Biology,Clinical Biochemistry,Physiology

Reference37 articles.

1. Osteoclasts have multiple roles in bone in addition to bone resorption;Boyce;Critical Reviews in Eukaryotic Gene Expression,2009

2. Osteoclast differentiation and activation;Boyle;Nature,2003

3. The role of cytokines in postmenopausal osteoporosis;Brincat;Minerva Ginecologica,2014

4. Estrogen deficiency induces bone loss by enhancing T-cell production of TNF-alpha;Cenci;The Journal of Clinical Investigation,2000

5. TNF and bone;David;Current Directions in Autoimmunity,2010

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