Quantitative Modeling Analysis Demonstrates the Impact of CYP2C19 and CYP2D6 Genetic Polymorphisms on the Pharmacokinetics of Amitriptyline and Its Metabolite, Nortriptyline-Reference-Cited by-同舟云学术

Quantitative Modeling Analysis Demonstrates the Impact of CYP2C19 and CYP2D6 Genetic Polymorphisms on the Pharmacokinetics of Amitriptyline and Its Metabolite, Nortriptyline

Published:2018-11-19 Issue:4 Volume:59 Page:532-540
ISSN:0091-2700
Container-title:The Journal of Clinical Pharmacology
language:en
Short-container-title:The Journal of Clinical Pharmacology

Author:

Koh Ara¹²,Pak Kwan Cheol¹²,Choi Hee Youn¹,Ryu Sunae³,Choi Seung-eun³,Kim Ki Soon³,Bae Kyun-Seop¹²,Lim Hyeong-Seok¹²

Affiliation:

1. Department of Clinical Pharmacology and Therapeutics; Asan Medical Center; Seoul Korea

2. University of Ulsan College of Medicine; Seoul Korea

3. Clinical Research Division; National Institute of Food and Drug Safety Evaluation; Cheongju-si Korea

Funder

Ministry of Food and Drug Safety

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/jcph.1344/fullpdf

Reference31 articles.

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4. CYP2D6 and CYP2C19 genotype-based dose recommendations for antidepressants: a first step towards subpopulation-specific dosages;Kirchheiner;Acta Psychiatr Scand,2001

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