Clinical, Health‐Related Quality of Life, and Gait Differences Among Obesity Classes in Adults With Knee Osteoarthritis

Author:

Messier Stephen P.1ORCID,Gill Malia E.1,Mihalko Shannon L.1,Beavers Daniel P.1,Queen Kate2,Miller Gary D.1,Losina Elena3ORCID,Katz Jeffrey N.3ORCID,Loeser Richard F.4ORCID,DeVita Paul5,Hunter David J.6ORCID,Quandt Sara A.1,Lyles Mary F.1,Hudson David7,Callahan Leigh F.4

Affiliation:

1. Wake Forest University Winston‐Salem North Carolina

2. Whole Health Partners Durham North Carolina

3. Brigham and Women's Hospital and Harvard Medical School Boston Massachusetts

4. University of North Carolina at Chapel Hill

5. East Carolina University Greenville North Carolina

6. University of Sydney Sydney Australia

7. Western Carolina University Cullowhee North Carolina

Abstract

ObjectiveThe purpose of this study was to determine whether clinical, health‐related quality of life (HRQL), and gait characteristics in adults with knee osteoarthritis (OA) differed by obesity category.MethodsThis cross‐sectional analysis of 823 older adults (mean age 64.6 years, SD 7.8 years) with knee OA and overweight or obesity compared clinical, HRQL, and gait outcomes among obesity classifications (overweight or class I, body mass index [BMI] 27.0–34.9; class II, BMI 35.0–39.9; class III BMI ≥40.0).ResultsPatients with class III obesity had worse Western Ontario McMasters Universities Arthritis Index knee pain (0–20) than the overweight or class I (mean 8.6 vs 7.0; difference 1.5; 95% confidence interval [CI] 1.0–2.1; P < 0.0001) and class II (mean 8.6 vs 7.4; difference 1.1; 95% CI 0.6–1.7; P = 0.0002) obesity groups. The Short Form 36 physical HRQL measure was lower in the class III obesity group compared to the overweight or class I (mean 31.0 vs 37.3; difference −6.2; 95% CI −7.8 to −4.7; P < 0.0001) and class II (mean 31.0 vs 35.0; difference −3.9; 95% CI −5.6 to −2.2; P < 0.0001) obesity groups. The class III obesity group had a base of support (cm) during gait that was wider than that for the overweight or class I (mean 14.0 vs 11.6; difference 3.3; 95% CI 2.6–4.0; P < 0.0001) and class II (mean 14.0 vs 11.6; difference 2.4; 95% CI 1.6–3.2; P < 0.0001) obesity groups.ConclusionAmong adults with knee OA, those with class III obesity had significantly higher pain levels and worse physical HRQL and gait characteristics compared to adults with overweight or class I or class II obesity. image

Funder

National Institute of Arthritis and Musculoskeletal and Skin Diseases

Publisher

Wiley

Subject

Rheumatology

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