Simultaneous and rapid determination of gefitinib, erlotinib and afatinib plasma levels using liquid chromatography/tandem mass spectrometry in patients with non-small-cell lung cancer

Author:

Hayashi Hideki12,Kita Yutaro1,Iihara Hirotoshi12,Yanase Koumei3,Ohno Yasushi3,Hirose Chiemi2,Yamada Maya2,Todoroki Kenichiro4,Kitaichi Kiyoyuki5,Minatoguchi Shinya3,Itoh Yoshinori2,Sugiyama Tadashi1

Affiliation:

1. Laboratory of Pharmacy Practice and Social Science; Gifu Pharmaceutical University; Gifu Japan

2. Department of Pharmacy; Gifu University Hospital; Gifu Japan

3. Second Department of Internal Medicine; Gifu University Graduate School of Medicine; Gifu Japan

4. Department of Analytical and Bio-Analytical Chemistry, School of Pharmaceutical Sciences; University of Shizuoka; Shizuoka Japan

5. Laboratory of Pharmaceutics; Gifu Pharmaceutical University; Gifu Japan

Publisher

Wiley

Subject

Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Biology,General Medicine,Biochemistry,Analytical Chemistry

Reference25 articles.

1. Simultaneous determination of nine tyrosine kinase inhibitors by 96-well solid-phase extraction and ultra performance LC/MS-MS;Bouchet;Clinica Chimica Acta,2011

2. Ethnic differences in response to epidermal growth factor receptor tyrosine kinase inhibitors;Calvo;Journal of Clinical Oncology,2006

3. Simultaneous quantification of erlotinib, gefitinib, and imatinib in human plasma by liquid chromatography tandem mass spectrometry;Chahbouni;Therapeutic Drug Monitoring,2009

4. A phase I dose escalation study of BIBW 2992, an irreversible dual inhibitor of epidermal growth factor receptor 1 (EGFR) and 2 (HER2) tyrosine kinase in a 2-week on, 2-week off schedule in patients with advanced solid tumours;Eskens;British Journal of Cancer,2008

5. European Medicines Agency Press Release. AstraZeneca withdraws its marketing authorisation application for Zactima (vandetanib) 2009 http://www.ema.europa.eu/docs/en_GB/document_library/Press_release/2009/11/WC500007024.pdf

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