Primed for change: The effect of a blood prime on peripheral blood stem cell collection and accuracy of a prediction tool in pediatric patients

Author:

Rahim Mahvish Q.123,Goebel W. Scott1234,Delph John4,Soundar Esther124

Affiliation:

1. Riley Hospital for Children at Indiana University Health Indianapolis Indiana USA

2. Indiana University School of Medicine Indianapolis Indiana USA

3. Pediatric Hematology, Oncology and Stem Cell Transplantation Indianapolis Indiana USA

4. Indiana University Health Apheresis Program Indianapolis Indiana USA

Abstract

AbstractPediatric apheresis collection of peripheral blood stem cells for autologous transplantation often requires use of a blood prime. We evaluated the relationship between pre‐apheresis blood CD34+ counts and final CD34+ yield with use of a blood prime. Forty patients underwent apheresis stem cell collection in a 5 year period in our hospital, of which 27 required blood priming of the apheresis machine. Despite the blood prime group having significantly higher pre‐apheresis CD34+ cell counts, this group processed a relatively higher volume of blood due to a higher dilutional effect and collected significantly less than predicted CD34+ cell yield. Use of weight‐specific collection efficiencies and dilution‐adjusted pre‐apheresis CD34+ counts will help in accurately estimating the whole blood volume to process for PBSC collection and therefore increase efficiency and decrease the overall cost of collection.

Publisher

Wiley

Subject

Hematology,General Medicine

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