Affiliation:
1. Department of Pediatrics and Adolescent Medicine Copenhagen University Hospital—Rigshospitalet Copenhagen Denmark
2. Department of Occupational Therapy and Physiotherapy Copenhagen University Hospital—Rigshospitalet Copenhagen Denmark
3. Department of Clinical Medicine Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark
4. Center for Clinical Research and Prevention Copenhagen University Hospital—Bispebjerg and Frederiksberg Frederiksberg Denmark
5. Institute of Clinical Medicine University of Copenhagen Copenhagen Denmark
6. University Hospitals Centre for Health Research (UCSF) Copenhagen University Hospital—Rigshospitalet Copenhagen Denmark
7. Department of Epidemiology and Cancer Control St. Jude Children's Research Hospital Memphis Tennessee USA
Abstract
AbstractObjectiveTo review the body of evidence on cardiorespiratory fitness, muscle strength, and physical performance in children with newly diagnosed cancer, five databases (MEDLINE, Embase, CINAHL, CENTRAL, and Web of Science) were searched on December 19, 2022.MethodsThirteen studies, embodying 594 participants within 1 month of cancer diagnosis and 3674 healthy controls were included. Eighteen different outcomes on cardiorespiratory fitness (n = 2), muscle strength (n = 5), physical performance (n = 10), and adverse events (n = 1) were analyzed.ResultsFifteen out of 17 outcomes on physical capacity showed severe impairments compared with healthy controls. Where possible, random‐effects meta‐analysis was conducted to synthesize the results. No adverse events were reported related to testing.ConclusionChildren with cancer have impaired cardiorespiratory fitness, muscle strength, and physical performance within the first month after diagnosis. However, the evidence is based on a small number of studies with large clinical heterogeneity, limiting the certainty of evidence.
Funder
Børnecancerfonden
Helsefonden
Dansk Kræftforsknings Fond
Kræftens Bekæmpelse
National Cancer Institute
Subject
Oncology,Hematology,Pediatrics, Perinatology and Child Health