Animal models for anti‐neutrophil cytoplasmic antibody‐associated vasculitis: Are current models good enough?

Author:

Huang Fei12,Lv Yongman34,Liu Siyang3,Wu Hao56,Liu Qingquan3ORCID

Affiliation:

1. Department of Geriatrics Tongji Hospital, Tongji Medical college, Huazhong University of Science and Technology Wuhan China

2. Department of General Medicine Tongji Hospital, Tongji Medical college, Huazhong University of Science and Technology Wuhan China

3. Department of Nephrology Tongji Hospital, Tongji Medical college, Huazhong University of Science and Technology Wuhan China

4. Department of health management center Tongji Hospital, Tongji Medical college, Huazhong University of Science and Technology Wuhan China

5. Interdisciplinary Sciences Institute Huazhong Agricultural University Wuhan China

6. State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine Huazhong Agricultural University Wuhan China

Abstract

AbstractAntineutrophil cytoplasmic autoantibody (ANCA)‐associated vasculitis (AAV) is a rare and severe systemic autoimmune disease characterized by pauci‐immune necrotizing inflammation of small blood vessels. AAV involves multiple organ systems throughout the body. Our knowledge of the pathogenesis of AAV has increased considerably in recent years, involving cellular, molecular and genetic factors. Because of the controlled environment with no other confounding factors, animal models are beneficial for studying the mechanistic details of disease development and for providing novel therapeutic targets with fewer toxic side effects. However, the complexity and heterogeneity of AAV make it very difficult to establish a single animal model that can fully represent the entire clinical spectrum found in patients. The aim of this review is to overview the current status of animal models for AAV, outline the pros and cons of methods, and propose potential directions for future research.

Publisher

Wiley

Subject

Medical Laboratory Technology,Veterinary (miscellaneous),Molecular Biology,Biochemistry,Medicine (miscellaneous)

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