Comparing the performance ofFAM19A4methylation analysis, cytology and HPV16/18 genotyping for the detection of cervical (pre)cancer in high-risk HPV-positive women of a gynecologic outpatient population (COMETH study)

Author:

Luttmer Roosmarijn1,De Strooper Lise M.A.1,Berkhof Johannes2,Snijders Peter J.F.1,Dijkstra Maaike G.3,Uijterwaal Margot H.4,Steenbergen Renske D.M.1,van Kemenade Folkert J.5,Rozendaal Lawrence1,Helmerhorst Theo J.M.6,Verheijen Rene H.M.7,Ter Harmsel W. Abraham8,Van Baal W. Marchien4,Graziosi Peppino G.C.M.9,Quint Wim G.V.10,Heideman Daniëlle A.M.1,Meijer Chris J.L.M.1

Affiliation:

1. Department of Pathology; VU University Medical Center, Amsterdam, The Netherlands

2. Department of Epidemiology and Biostatistics; VU University Medical Center; Amsterdam The Netherlands

3. Department of Obstetrics and Gynecology; VU University Medical Center; Amsterdam The Netherlands

4. Department of Obstetrics and Gynecology; Flevo Hospital; Almere The Netherlands

5. Department of Pathology; Erasmus Medical Center; Rotterdam The Netherlands

6. Department of Obstetrics and Gynecology; Erasmus MC University Medical Center; Rotterdam The Netherlands

7. Department of Obstetrics and Gynecology; University Medical Center Utrecht; Utrecht The Netherlands

8. Department of Gynecology; Roosevelt Clinic; Leiden The Netherlands

9. Department of Obstetrics and Gynecology; Sint Antonius Hospital; Nieuwegein The Netherlands

10. DDL Diagnostic Laboratory; Rijswijk The Netherlands

Funder

KWF Kankerbestrijding

European Research Council

Seventh Framework Programme

Publisher

Wiley

Subject

Cancer Research,Oncology

Reference50 articles.

1. Clinical implications of (epi)genetic changes in HPV-induced cervical precancerous lesions;Steenbergen;Nat Rev Cancer,2014

2. Human papillomavirus is a necessary cause of invasive cervical cancer world-wide;Walboomers;J Pathol,1999

3. Human papillomavirus and Papanicolaou tests to screen for cervical cancer;Naucler;N Engl J Med,2007

4. Efficacy of HPV-based screening for prevention of invasive cervical cancer: follow-up of four European randomised controlled trials;Ronco;Lancet,2013

5. Primary human papillomavirus testing in organized cervical screening;Dillner;Curr Opin Obstet Gynecol,2013

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