Stability of doripenem in reconstituted solution - thermal and oxidative decomposition kinetics and degradation products by LC-MS

Author:

de Souza Barbosa Fábio1,Cassol José Pedro Etchepare1,Batista Luiz Alcides das Chagas2,Cordeiro Everson Willian Fialho2,Santos Marí Castro3,Pohlmann Adriana Raffin3,Schapoval Elfrides E. S.3,Garcia Cássia Virginia3,Mendez Andreas Sebastian Loureiro13ORCID

Affiliation:

1. Programa de Pós-graduação em Ciências Farmacêuticas; Universidade Federal do Pampa; BR 472 Km 585 CEP 97508-000 Uruguaiana RS Brazil

2. Laboratório de Desenvolvimento e Controle de Qualidade de Medicamentos; Universidade Federal do Pampa; BR 472 Km 585 CEP 97508-000 Uruguaiana RS Brazil

3. Programa de Pós-graduação em Ciências Farmacêuticas; Universidade Federal do Rio Grande do Sul; Avenida Ipiranga 2752 CEP 90610-000 Porto Alegre RS Brazil

Publisher

Wiley

Subject

Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Biology,General Medicine,Biochemistry,Analytical Chemistry

Reference33 articles.

1. The role of degradant profiling in active pharmaceutical ingredientes and drug products;Alsante;Advanced Drug Delivery Reviews,2007

2. AMC 2013 Experimental design and optimisation (4): Plackett-Burman designs

3. Chromatographic determination of polymerized impurities in meropenem;Cai;Journal of Pharmaceutical and Biomedical Analysis,2005

4. The UV-derivative spectrophotometry for the determination of doripenem in the presence of its degradation products;Cielecka-Piontek;Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy,2010

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