Affiliation:
1. Department of Otolaryngology – Head & Neck Surgery University of Virginia Charlottesville Virginia USA
2. School of Medicine University of Virginia Charlottesville Virginia USA
3. Department of Radiology and Medicine Imaging University of Virginia Charlottesville Virginia USA
4. Department of Pathology University of Virginia Charlottesville Virginia USA
Abstract
AbstractBackgroundOncocytic carcinoma (OCA) was recently reclassified as a distinct differentiated thyroid carcinoma (DTC). Given its rarity, OCA studies are limited. This study describes the characteristics of OCA in a 20‐year cohort.MethodsRetrospective analysis of patients with OCA at a single tertiary care hospital from 2000 to 2021.ResultsFifty‐one OCA patients (22M:29F) were identified. The mean age at diagnosis was 60.3 years; 90% presented as palpable mass; 24% had a family history of thyroid cancer. None had vocal fold paresis. On ultrasound, most tumors were solid and hypoechoic. FNA (n = 14) showed Bethesda‐4 lesions in 93%. All were treated surgically. Histologically, 63% demonstrated angioinvasion, 35% had lymphovascular invasion, and 15% had extrathyroidal extension. Radioactive iodine was used as adjunct therapy in 77%.ConclusionOCA has distinct features that distinguish it from other DTCs, and additional focused studies will help clarify the aggressive nature, treatment options, and prognosis of the disease.