Synthesis of isotopically labelled [14C]ZT-1 (Debio-9902), [d3]ZT-1 and (−)-[d3]huperzine A, a new generation of acetylcholinesterase inhibitors-Reference-Cited by-同舟云学术

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Synthesis of isotopically labelled [14C]ZT-1 (Debio-9902), [d3]ZT-1 and (−)-[d3]huperzine A, a new generation of acetylcholinesterase inhibitors

Published:2011-09 Issue:11 Volume:54 Page:720-730
ISSN:0362-4803
Container-title:Journal of Labelled Compounds and Radiopharmaceuticals
language:en
Short-container-title:J. Label Compd. Radiopharm

Author:

Leman Loïc¹,Kitson Sean L¹,Brown Rodney T¹,Cairns Jana¹,Watters William¹,McMordie Austin¹,Murrell Victor L¹,Marfurt Judith²

Affiliation:

1. Isotope Chemistry Laboratories, Almac; Almac House, 20 Seagoe Industrial Estate; Craigavon; BT63 5QD; UK

2. Debiopharm S.A.; Forum Après-demain; Chemin Messidor 5-7; CP 5911-1002; Lausanne; Switzerland

Publisher

Wiley

Subject

Organic Chemistry,Spectroscopy,Drug Discovery,Radiology Nuclear Medicine and imaging,Biochemistry,Analytical Chemistry

Reference33 articles.

1. The structures of huperzine A and B, two new alkaloids exhibiting marked anticholinesterase activity

2. A practical synthesis of the Chinese "nootropic" agent huperzine A: a possible lead in the treatment of Alzheimer's disease

3. Synthesis of huperzine A, its analogs, and their anticholinesterase activity

4. An improved synthetic route to huperzine A; new analogues and their inhibition of acetylcholinesterase

5. A total synthesis of (±)-huperzine A

Cited by 4 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. The Curtius rearrangement: mechanistic insight and recent applications in natural product syntheses;Organic & Biomolecular Chemistry;2018

2. Inhibitors of Acetylcholinesterase and Butyrylcholinesterase Meet Immunity;International Journal of Molecular Sciences;2014-06-02

3. Selected Scientific Topics of the 11th International Isotope Symposium on the Synthesis and Applications of Isotopes and Isotopically Labeled Compounds;Journal of Labelled Compounds and Radiopharmaceuticals;2013-07

4. 2,3-Dihydro-1H-cyclopenta[b]quinoline Derivatives as Acetylcholinesterase Inhibitors—Synthesis, Radiolabeling and Biodistribution;International Journal of Molecular Sciences;2012-08-13

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