One‐pot synthesis of unsymmetrical 1,3‐butadiyne derivatives

Abstract

AbstractAn efficient co‐operative Ni/Cu system for Cadiot–Chodkiewicz coupling utilizes CaC2 as the alkyne source. The advantage of this cross‐coupling reaction lies in the low cost of using cheap and readily available raw materials and the simplicity of operation. A series of functionalized diaryl, aryl‐alkyl, and aryl‐heteroaryl 1,3‐diynes are obtained in moderate to high yields.