Abnormalities of the Descending Inhibitory Nociceptive Pathway in Functional Motor Disorders-Reference-Cited by-同舟云学术

Abnormalities of the Descending Inhibitory Nociceptive Pathway in Functional Motor Disorders

Published:2024-03-12 Issue:5 Volume:39 Page:905-910
ISSN:0885-3185
Container-title:Movement Disorders
language:en
Short-container-title:Movement Disorders

Author:

Squintani Giovanna¹,Geroin Christian²^ORCID,Pasquali Alessia²,Cavazzana Eleonora²,Segatti Alessia¹,Lippolis Marianna¹,Bonetto Chiara³,Antelmi Elena⁴^ORCID,Tinazzi Michele²^ORCID

Affiliation:

1. Neurology and Neurophysiology Unit Azienda Ospedaliera Universitaria Integrata Verona Italy

2. Neurology Unit, Movement Disorders Division, Department of Neurosciences, Biomedicine and Movement Sciences University of Verona Verona Italy

3. Psychiatry Section, Department of Neurosciences, Biomedicine and Movement Sciences University of Verona Verona Italy

4. Neurology Unit, Movement Disorder Division, Department of Engineering for Innovation Medicine University of Verona Verona Italy

Abstract

AbstractBackgroundPain is a common disabling non‐motor symptom affecting patients with functional motor disorders (FMD).ObjectiveWe aimed to explore ascending and descending nociceptive pathways with laser evoked potentials (LEPs) in FMD.MethodsWe studied a “bottom‐up and top‐down” noxious paradigm applying a conditioned pain modulation (CPM) protocol and recorded N2/P2 amplitude in 21 FMD and 20 controls following stimulation of both right arm and leg at baseline (BS) (bottom‐up), during heterotopic noxious conditioning stimulation (HNCS) with ice test (top‐down) and post‐HNCS.ResultsWe found a normal ascending pathway, but reduced CPM response (lower reduction of the N2/P2 amplitude) in FMD patients, by stimulating both upper and lower limbs. The N2/P2 amplitude ratio*100 (between the HNCS and BS) was significantly higher in patients with FMD than HC.ConclusionsOur results suggest that pain in FMD possibly reflects a descending pain inhibitory control impairment, therefore, providing a novel venue to explore the pathophysiology of pain in FMD. © 2024 International Parkinson and Movement Disorder Society.

Publisher

Wiley

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