Recent attempts at RNAi-mediated P-glycoprotein downregulation for reversal of multidrug resistance in cancer

Author:

Abbasi Meysam1,Lavasanifar Afsaneh23,Uludaˇ Hasan123

Affiliation:

1. Department of Biomedical Engineering, Faculty of Medicine; University of Alberta; Edmonton Canada

2. Faculty of Pharmacy and Pharmaceutical Sciences; University of Alberta; Edmonton Canada

3. Department of Chemical and Materials Engineering, Faculty of Engineering; University of Alberta; Edmonton Canada

Funder

Canadian Institutes of Health Research

Natural Sciences and Engineering Council of Canada

Alberta Advanced Education and Technology

Alberta Heritage Foundation for Medical Research

Publisher

Wiley

Subject

Drug Discovery,Pharmacology,Molecular Medicine

Reference80 articles.

1. Molecular and physiologic mechanisms of drug resistance in cancer: An overview;Kerbel;Can Metas Rev,2001

2. Chemotherapy-induced resistance by ATP-binding cassette transporter genes;Gillet;Biochim Biophys Acta,2007

3. ABC efflux pump-based resistance to chemotherapy drugs;Eckford;Chem Rev,2009

4. Multiple drug resistance mechanisms in cancer;Baguley;Mol Biotechnol,2010

5. Recent progress in understanding the mechanism of P-glycoprotein-mediated drug efflux;Loo;J Membr Biol,2005

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