Clinical characteristics and factors for serious outcomes among outpatients infected with the Omicron subvariant BF.7

Author:

Yang Hui1,Wang Zhaojian12,Zhang Ying123,Xu Man123,Wang Yushu1,Zhang Yi1,Liu Xuefeng4ORCID,An Zhuoling1,Tong Zhaohui5ORCID

Affiliation:

1. Department of Pharmacy, Beijing Chao‐Yang Hospital Capital Medical University Beijing China

2. Department of Clinical Pharmacy, School of Pharmaceutical Science Capital Medical University Beijing China

3. Department of Pharmacy, Beijing Obstetrics and Gynecology Hospital Capital Medical University Beijing China

4. Departments of Pathology, Urology, and Radiation Oncology The Ohio State University Columbus Ohio USA

5. Department of Respiratory and Critical Care Medicine Beijing Institute of Respiratory Medicine Beijing China

Abstract

AbstractTo evaluate clinical characteristics and identify risk factors associated with severe outcomes in outpatients infected with the Omicron subvariant BF.7, data were collected from outpatients diagnosed with Corona Virus Disease 2019 from December 19, 2022 to January 5, 2023. Clinical characteristics were analyzed using descriptive statistics. Univariate and multivariate logistic regression analyses were conducted to identify factors associated with serious outcomes. Variables with a p < 0.10 in the univariate analysis were included in the multivariate model. Our study analyzed 770 patients, of whom 380 (49.4%) were male, with a median age of 59. The most common symptoms reported were cough (71.2%), fever (64.7%), and sore throat (37.7%). Fever lasted an average of 5.93 ± 3.37 days for the general population and 10.64 ± 7.12 days for impaired‐immunity patients. Most cases were mild (68.7%), followed by moderate (27.1%). Severe cases accounted for 2.2%, with 0.5% critically ill. Serious outcomes occurred in 4.2% of cases, with 11 deaths during follow‐up. Underlying‐diseases patients had a higher rate of serious outcomes. Factors associated with serious outcomes included receiving a three‐dose vaccination (odds ratio [OR] = 0.324, 95% confidence interval [CI]: 0.113–0.932, p = 0.037), male gender (OR = 2.890, 95% CI: 1.107–7.548, p = 0.030), age (OR = 1.060, 95% CI: 1.024–1.097, p = 0.001), and chest tightness or dyspnea at the time of visit (OR = 4.861, 95% CI: 2.054–11.507, p < 0.001). Our study found that cough, fever, and sore throat were the most common symptoms reported by patients. Receiving a three‐dose vaccination was protective, while male gender, age, and chest tightness or dyspnea were identified as risk factors for serious outcomes.

Publisher

Wiley

Subject

Infectious Diseases,Virology

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